Association of EASIX in Sepsis

Association of Endothelial Activation and Stress Index With Mortality and Poor Prognosis in Sepsis: A Prospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06887439

Enrollment

150

Registered

2025-03-20

Start date

2024-06-01

Completion date

2025-12-01

Last updated

2026-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis, Septic Shock, Septic Syndrome

Keywords

sepsis, septic shock, endothelium

Brief summary

This prospective study aims to determine the relationship between the EASIX score and mortality and prognosis in sepsis.

Detailed description

Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to organ dysfunction. Despite advancements in medicine, sepsis remains a significant cause of death worldwide. An international study showed that 48.9 million sepsis cases were diagnosed in 195 countries between 1990 and 2017, resulting in 11 million deaths. Recent studies have demonstrated that early diagnosis and treatment reduce sepsis mortality. Therefore, research has focused on identifying biomarkers that aid in early diagnosis and prognosis. The Endothelial Activation and Stress Index (EASIX) was first defined by Luft et al. as a biomarker reflecting endothelial damage. Calculated using readily available laboratory parameters-serum lactate dehydrogenase (LDH) level (U/L) x creatinine level (mg/dL) / platelet count (10⁹/L)-it has been commonly used to predict mortality and prognosis in hematological malignancies. Recently, its application in predicting sepsis mortality and prognosis has gained attention, although only limited retrospective studies have been published.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* • Patients diagnosed with sepsis during intensive care admission or admitted to intensive care with a diagnosis of sepsis * All patients over the age of 18

Exclusion criteria

* • Patients under the age of 18 * Patients with a history of multiple intensive care admissions * Patients who died within 24 hours of diagnosis * Patients diagnosed with CRF or currently treated for ARF * Patients with deficient serum creatinine, LDH and platelet values at the time of diagnosis Patients for whom consent could not be obtained from themselves or their relatives

Design outcomes

Primary

Measure	Time frame	Description
mortality	28 days	The primary finding of the study was 28-day mortality after sepsis diagnosis

Secondary

Measure	Time frame	Description
Septic shock	28 days	Septic shock was defined according to the SEPSIS-3 guidelines as the need for vasopressors or inotropes in patients diagnosed with sepsis.
Acute kidney injury	28 days	Acute kidney injury was defined according to KDIGO guidelines as a ≥0.3 mg/dL increase in serum creatinine over 48 hours, a ≥1.5-fold increase in serum creatinine over 7 days, or urine output \<0.5 mL/kg/hour for 6 consecutive hours.

Countries

Turkey (Türkiye)

Contacts

STUDY_CHAIRAYSE SURHAN CINAR

şişli etfal eğitim araştırma hastanesi

Outcome results