Probiotics for Preterm Infants

Probiotics for Preterm Infants After Full Enteral Feeding

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06885944

Enrollment

100

Registered

2025-03-20

Start date

2025-03-30

Completion date

2025-11-30

Last updated

2025-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Infant Feeding Outcomes, Probiotic

Brief summary

Probiotics will be used for preterm infants under 32 weeks of gestation and under 1500 g birthweight. Our aim was to investigate the effects of probiotics for stable preterm infants after extubation and who reached full enteral feeding. There are some hesitations among care-givers to start probiotics early due to safety issues although there are many positive effects of these products reported int the literature.

Detailed description

Our study included premature babies with a birth weight of less than 1500 grams, born at less than 32 weeks of gestation, and without congenital anomalies. Approval was obtained from the hospital's clinical research ethics committee before starting the study. The decision to start probiotics was made when these premature babies were fully enteral fed. The study design was created as a cohort and case-control study (No randomisation). When clinicians decided to start probiotic support for premature babies with good general health and no additional problems, probiotics were added to the baby's order.

Interventions

DIETARY_SUPPLEMENTProbiotic mix preparation

Bifidobacterium containing supplement with vitamin D will start after preterm infants reaches full enteral feeding

DIETARY_SUPPLEMENTBifidobacteria

Rather than early period we will start probiotics after infant receive full enteral feedings

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

7 Days to 3 Months

Healthy volunteers

Inclusion criteria

\<32 weeks, \<1500 g birthweight -

Exclusion criteria

Congential anomalies, still parenteral feeding, BW\<800 gr and \<23 weeks of GA \-

Design outcomes

Primary

Measure	Time frame	Description
Antropometric measures	2 months	daily weight gain mg/kg/day

Secondary

Measure	Time frame	Description
Metabolic profile	2 months	Ca, P, ALP, Urea and biochmeical markers for nutritional status

Contacts

Primary ContactSeray Ozturk, MD

serayakbag@gmail.com+905310843200

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026