Colorectal Cancer, Metastasis, Prognosis, Survival, Tumor Deposits
Conditions
Brief summary
This study aims to evaluate the tumor deposits in colorectal cancer and its prognostic value in survival and metastasis
Detailed description
Tumor deposits (TDs) are defined as isolated tumor foci found in the pericolonic or perirectal fat or the adjacent mesentery (mesocolonic fat) away from the invasive margin of the tumor without evidence of residual lymphatic tissue. TDs are significantly correlated with poor prognosis after colorectal cancer surgery.
Interventions
PROCEDURETherapeutic resection
Patients with colorectal cancer underwent therapeutic resection with pathologically positive tumor deposits (TDs) to determine distant metastasis occurrence and the effect of TDs on survival.
Sponsors
Minia University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age above 18 years old. * Both sexes. * All Colorectal cancer patients From Stage I to III Colorectal cancer with pathologically positive Tumor deposits.
Exclusion criteria
* Patient took neoadjuvant therapy. * No information available on tumor deposits. * Colorectal cancer is not the only primary cancer. * Patients with incomplete information about follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patients' overall survival | 2 years postoperatively | Patients' overall survival (OS) is defined as from colorectal cancer (CRC) diagnosis to death. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Distant metastasis | 2 years postoperatively | Distant metastasis is defined as the presence of liver, lung, bone, or brain metastases during or after colorectal cancer (CRC) diagnosis. |
Countries
Egypt
Outcome results
None listed