Gestational Diabetes Mellitus (GDM)
Conditions
Brief summary
The aim of this study is to investigate the placental inflammation in women with gestational diabetes mellitus, in particular the role of inflammasome NLRP3 and the chemokine scavenger decoy receptor D6
Detailed description
The aim of this study is to investigate systemic and placental inflammation in women with gestational diabetes mellitus, in particular the role of inflammasome NLRP3 and the chemokine scavenger decoy receptor D6, compared to women with uncomplicated pregnancy
Interventions
Blood sampling
OTHERPlacental Extract
Placental sampling after caesarean section
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Women with gestational diabetes mellitus * Women with uncomplicated pregnancy * Age \>18 years * Singleton pregnancy
Exclusion criteria
* Age \< 18 years * Infections (HIV,HCV) * Multiple pregnancy * Cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Placental inflammation | At delivery/birth | Analysis of protein expression of inflammasome NLRP3 and D6 scavenger receptor in placental tissue. |
Countries
Italy
Outcome results
None listed