Unique Electroencephalography (EEG) Markers of Habit Behaviors in Obsessive-Compulsive Disorder (OCD)

Using Forced-response Model and Drift-diffusion Model to Explore OCD's Unique Electroencephalographic Markers of Habit Formation and Expression

Status

Enrolling by invitation

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06882902

Enrollment

Registered

2025-03-19

Start date

2024-05-05

Completion date

2025-07-30

Last updated

2025-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-Compulsive Disorder

Keywords

habit, cognitive flexibility, response inhibition

Brief summary

This study focuses on explaining the occurrence and development of compulsive behaviors from habit hypothesis. Investigators will study both OCD patients and healthy individuals using Hardwick's forced-response time task(2019), the habit Go/No-Go task, and the Intra-Extra Dimensional Set Shift task. Investigators aim to explore the cognitive abilities and differences between OCD patients and healthy controls in these three tasks. Control variables will include participants' levels of anxiety, depression, and stress, as well as sense of incompleteness and intolerance of uncertainty levels. By examining the differences in habit formation and expression abilities between OCD patients and healthy controls, and exploring the specific brain electroencephalographic activity processes in OCD patients, investigators hope to reveal the abnormal neural activity in habit-related circuits in OCD patients. This could provide new insights for the diagnosis and treatment of OCD.

Interventions

BEHAVIORALhabit formation training

Participants need to perform habit formation exercises for 4 consecutive days. During the exercises, participants will see a picture stimulus and need to learn the corresponding key press. Each day, participants will spend 30 minutes on the training.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1. Aged between 18 and 50; 2. Y-BOCS score greater than or equal to 16; 3. Meet DSM-5 diagnostic criteria with no medication changes in the past two weeks; 4. Right-handed.

Exclusion criteria

1. Diagnosed with any DSM-5 disorder other than OCD; 2. Have a major physical illness; 3. Have strong suicidal ideation.

Design outcomes

Primary

Measure	Time frame	Description
Reduction of Y-BOCS scores	baseline#after- intervention#1 weeks# (pre-intervention, after intervention, one weeks after intervention)	We defined the habit training response as the percent reduction of Y-BOCS scores greater than or equal to 35%.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026