Cardiac Surgery Requiring Cardiopulmonary Bypass
Conditions
Keywords
cardiac surgery, viscoelastic testing, point-of-care, ROTEM, cardiopulmonary bypass, bleeding
Brief summary
The goal of this observational study is to determine the relationship of ROTEM point-of-care coagulation assay parameters with excessive bleeding and clinical outcomes in patients undergoing cardiac surgery at Toronto General Hospital. The main questions it aims to answer are: i) How well does viscoelastic testing (VET) predict the clinical outcome of excessive bleeding in cardiac surgery? ii) Which VET parameters have the greatest accuracy for identification of patients who will have excessive bleeding? iii) 3) What is the prognostic value of abnormal VET parameters with other clinical outcomes after cardiac surgery?
Interventions
OTHERNo intervention (observational study)
This is an observational study. No intervention.
Sponsors
University Health Network, Toronto
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients ≥ 18 years old * Underwent a cardiac surgical procedure with cardiopulmonary bypass
Exclusion criteria
\- Did not undergo viscoelastic testing during surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Excessive bleeding | From the end of bypass to the end of postoperative day-1 (POD1) | Measured by the universal definition of perioperative bleeding (UDPB) scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Transfusion rate | 1) From time of entry to operating room (OR) to the end of post-operative day-1 (POD1) and post-operative day-7(POD7). 2) from end of cardiopulmonary bypass (CPB) to the end of post-operative day-1 (POD1) and post-operative day-7 (POD7) | Incidence and amount of transfusion of allogeneic blood products and factor concentrates |
Contacts
Primary ContactKeyvan Karkouti
Backup ContactDeep Grewal
Outcome results
None listed