Spinal Cord Injuries
Conditions
Keywords
postprandial hypotension, electrical stimulation, low-glycemic diet
Brief summary
The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.
Interventions
OTHERLow glycemic load
Low glycemic load diet
OTHERElectrical stimulation exercise
Lower-body electrical stimulation exercise for 1-h after eating
High glycemic load diet
Sponsors
Ohio State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Spinal cord injury (SCI) between C4 and T12 who require use of wheelchair for daily mobility * AIS A or B * \>1-year post-injury
Exclusion criteria
* Currently pregnant of breast-feeding * Type 1 or 2 diabetes * Previous gut augmentation bariatric surgery * Neurological impairment other than SCI * History of uncontrolled autonomic dysreflexia * History of bone fractures * Use of abdominal binder or anti-hypotensive drugs * Fitted with pacemaker or defibrillator * Currently receiving electrical stimulation training or in the previous year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Magnitude of systolic blood pressure decrease (in-lab) | Visit 2-4, Day 1 | Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast and lunch under laboratory-controlled conditions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Magnitude of systolic blood pressure decrease (at-home) | Visits 2-4, Days 1-3 | Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast, lunch, and dinner for 3-days during at-home testing |
| Postprandial glucose (in-lab) | Visits 2-4, Day 1 | Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions. |
| Postprandial insulin (in-lab) | Visits 2-4, Day 1 | Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions. |
| Postprandial glucose (at-home) | Visits 2-4, Day 1-3 | A continuous glucose monitor will be used to measure glucose for 2-h after breakfast, lunch, and dinner for 3-days during at-home testing |
| Blood flow (in-lab) | Visits 2-4, Day 1 | Blood flow at the radial, brachial, popliteal and superior mesenteric arteries will be obtained using Doppler imaging at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions. |
Countries
United States
Contacts
Primary ContactMatthew Farrow, PhD
Backup ContactCeren Yarar-Fisher, PhD
Outcome results
None listed