Hepatitis B Virus, Inflammatory Bowel Disease (IBD)
Conditions
Keywords
Hepatitis b virus, Inflammatory bowel disease course
Brief summary
The goal of this observational retrospective study is to assess the impact of hepatitis B virus (HBV) infection on the clinical course and outcomes of inflammatory bowel disease (IBD) in Egyptian patients. Researchers will compare the IBD extent, location, severity, and behavior between IBD patients with and without HBV infection. Participants will be subjected to history-taking (history of hospital admission and disease flare, surgical history, medication history, follow-up duration, and mortality), clinical examination, laboratory investigations, abdominal ultrasonography, and endoscopic examination.
Interventions
OTHERHistory of IBD course and outcome in HBV patients
Full history taking including: * Personal history (name, age, sex, occupation, residence, and marital state). * Complaint. * Age at diagnosis of IBD. * Medication history. * History of hospital admissions and disease flares. * Disease extent, location, and behavior. (Montreal classification, Truelove-Witts severity index). * Surgical history (intestinal resection in CD patients and total proctocolectomy in UC patients). * Follow up duration and mortality. * Data of endoscopic examination * Data of laboratory investigations (complete blood picture, HBV serology, liver and kidney function tests, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)).
Sponsors
Tanta University
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female patients older than 18 years. * Patients with IBD are diagnosed by clinical, radiological, endoscopic, and histological criteria.
Exclusion criteria
* Patients aged \< 18 years * Unwilling to participate in our study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with severe IBD measured by Truelove-Witts severity index | through study completion, an average of 6 month | comparing IBD extent, location, and behavior using Montreal classification, Truelove-Witts severity index between patients with and without HBV infection |
| Hospital admission rates in IBD patients | through study completion, an average of 6 month | comparing IBD hospital admission rates between patients with and without HBV infection |
| number of IBD patients undergoing surgical treatment | through study completion, an average of 6 month | comparing surgical treatment rates (intestinal resection in CD patients and total proctocolectomy in UC patients) for IBD between patients with and without HBV infection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease flares rates in IBD patients | through study completion, an average of 6 months | comparing IBD disease flare rate between patients with and without HBV infection. |
| mortality rates in IBD patients | through study completion, an average of 6 months | comparing IBD mortality rates between patients with and without HBV infection. |
Countries
Egypt
Contacts
Primary ContactRania M Elkafoury, MD
Backup ContactNabila A Elgazzar, MD
Outcome results
None listed