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Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars

Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars: a Randomized Controlled Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06880952
Acronym
RITOR
Enrollment
145
Registered
2025-03-18
Start date
2021-09-01
Completion date
2022-08-19
Last updated
2025-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Third Molars Extraction

Keywords

third molar, chlorhexidine

Brief summary

This study aimed to assess the impact of postoperative chlorhexidine use on pain management following mandibular third molar removal In this prospective, randomized controlled trial,130 patients who underwent mandibular third molar surgical removal were divided into two groups: one group used chlorhexidine for postoperative rinsing and the other did not rinse. Pain levels, measured using the Numeric Rating Scale (NRS), were recorded daily for the first seven days post-surgery. Paired-samples t-tests were utilized for data analysis.

Interventions

In the rinsing group, the patients received a bottle of 0,2% chlorhexidine

Sponsors

Isala
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

• healthy adults (18+) referred by their dentist for third molar removal

Exclusion criteria

* active pericoronitis or other infections * planned coronectomy * trismus * chronic pain * pregnancy * known allergies to local anesthesia

Design outcomes

Primary

MeasureTime frameDescription
Postoperative pain after removal of third molar7 days after the inclusion pain was measured on a numerical rating scaleThe primary endpoint is the difference in the postoperative pain measured on a numerical rating scale (NRS) evaluated at seven days

Secondary

MeasureTime frameDescription
Post-operative complications7 days after the treatment the patient was seen at the outpatient clinic for clinical assessment. At this moment the number of patients with alveolitis, foodimpaction and bleeding was scored.As secondary outcome measures alveolitis, foodimpaction, bleeding or infection

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026