Acute Chest Syndrome, Sickle Cell Disease
Conditions
Keywords
Sickle Cell Disease, Sickle Cell Anemia, Acute Chest Syndrome, POCUS, Ultrasound
Brief summary
Feasibility and reliability of ultrasound in the inpatient hematology setting.
Detailed description
Acute chest syndrome (ACS) is a complication of sickle cell disease where individuals have symptoms of fever, low oxygen levels or difficulty breathing in the setting of a new lung finding on chest x-ray. Chest x-ray is a useful tool to identify it but has some side effects. The investigators think ultrasound will be an equally feasible, reliable tool and minimize some of the side effects associated with chest x-ray. Ultrasound is a non-invasive was to obtain an image that does not require radiation.
Interventions
DEVICEPoint of Care Ultrasound
Point of Care Ultrasound during hospitalization
Sponsors
Indiana University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 25 Years
Healthy volunteers
No
Inclusion criteria
1. Age: 0-25 years old 2. Diagnosis: Patients with a documented diagnosis of sickle cell disease (any genotype) 3. Disposition: Hospitalized for a SCD-related complication (e.g. VOC)
Exclusion criteria
1. Patient is considered hemodynamically unstable to undergo consent and study procedures 2. Already has diagnosis of ACS prior to admission to inpatient unit 3. POCUS operator not available
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Participation rate | Up to 5 days | Percentage of patients who are approached for study who agree to be on study |
| Retention rate | Up to 5 days | Percentage of patients who remain on study |
| Duration of exam | Up to 5 days | Time taken to complete POCUS examination |
| Acceptability of POCUS by the medical team (physicians and nursing) | Up to 5 days | Acceptability measured using a 5-point Likert Scale (Strongly Agree to Strongly Disagree) regarding use of POCUS in inpatient setting. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reliability of point of care ultrasound (POCUS) compared to standard of care (Chest X-ray) | Up to 5 days | A positive screening of acute chest syndrome by POCUS is identification of either a lung consolidation or focal B-lines. POCUS findings will be compared to standard of care (Chest X-ray) findings to see if findings concur. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORSeethal Jacob, MD
Indiana University
Outcome results
None listed