Diabetes Mellitus Type 2
Conditions
Brief summary
The goal of this trial is to test the effect of house cricket (Acheta domesticus) preload on glycemic response in diabetic patients. The main question\[s\] it aims to answer are: whether house cricket powder could lower blood glucose spike and stimulate higher insulin response. Participants will consume either house cricket powder, whey protein isolate or placebo which will be mixed with a chicken-flavored soup. Participants fingers will be pricked for up to 2 hours. Researcher will compare house cricket powder with placebo to see if the glycemic response is better in house cricket supplemented group. Researcher will compare house cricket powder with whey protein isolate to see if both supplement induce comparable glycemic response.
Detailed description
Participants blood will be collected at 8 time points: Baseline 20 minutes after pre load 15 minutes after Oral Glucose Tolerance Test (OGTT) 30 minutes after OGTT 45 minutes after OGTT 60 minutes after OGTT 90 minutes after OGTT 120 minutes after OGTT
Interventions
DIAGNOSTIC_TESTOral Glucose Tolerance test (75g 2-hour)
The participants are required to drink a glucose solution containing 75 g of glucose dissolved in 250 mL of water
DIETARY_SUPPLEMENTWhey
Supplemented with whey protein isolate masked with a chicken-flavored soup
DIETARY_SUPPLEMENTHouse cricket
Supplemented with house cricket powder masked with chicken-flavored soup
DIETARY_SUPPLEMENTPlacebo
Placebo consists of chicken-flavored soup without any supplement inside
Sponsors
University of Malaya
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Intervention model description
Randomized, Cross over, Controlled Trial
Eligibility
Sex/Gender
MALE
Healthy volunteers
No
Inclusion criteria
* Suffering from type 2 diabetes mellitus (HbA1c \> 6.5%) * Consume metformin for at least 6 months
Exclusion criteria
* Consume other type of anti-diabetic drugs * Presenting any food allergy * Recent surgery or infections that may affect oral glucose tolerance test * Consume other drugs that may affect oral glucose tolerance test * Not consuming any anti-diabetic drugs * Pre-diabetes (HbA1c 5.7 - 6.4%)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose | 120 minutes | Blood glucose concentration measured using glucometer. Participants fingers are pricked and using capillary tube, a drop of the blood is dripped in a test strip before inserted to a glucometer. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood insulin | 120 minutes | Blood sample is collected through a finger prick. The blood will be centrifuged to obtain the serum. Insulin serum concentration is then measured by using ELISA kits. The blood sample are treated following the kit guideline, and the insulin concentration are measured by comparing the light absorbance against a prepared standard. |
Countries
Malaysia
Outcome results
None listed