Cardiometabolic Conditions, Mental Health, Psychological Stress
Conditions
Brief summary
Volunteers for the study are asked to participate in two laboratory sessions. In the first laboratory session, volunteers are asked to provide a blood sample which will be used to measure factors related to health. Participants also complete questionnaires related to demographic and health-related information and undergo evaluations of their body composition. In the second laboratory visit, participants are asked to have cardiovascular, neuroendocrine, and inflammatory activity measured during a brief period of rest and during a short challenging psychological task. Participants will also complete questionnaires. The study is designed to examine the associations between experiences such as trauma and resiliency with changes in bodily systems during a challenge and current health.
Detailed description
This cross-sectional study will examine the association between factors of resiliency and trauma with physiological (cardiovascular, neuroendocrine, inflammatory) responses to acute stress and current mental and physical health. Study volunteers will include individuals who identify as American Indian and currently live on and near the Blackfeet Reservation. Study volunteers will be asked to provide information that will be used to measure: correlates of cardiometabolic and mental health, acute psychological stress, arterial stiffness. Results of the study will help increase knowledge of cardiometabolic and mental health in the context of past and ongoing trauma and resiliency.
Interventions
BEHAVIORALAcute psychological stress task (Paced Auditory Serial Addition Task)
Volunteers will complete a 4-minute Paced Auditory Serial Addition Task which is a standardized laboratory challenge that is widely used to monitor cardiovascular, neuroendocrine, and inflammatory responses in the laboratory.
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Baylor University
Blackfeet Community College
Montana State University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
The study is designed to examine cardiovascular, neuroendocrine, and inflammatory responses to a brief (4 minutes) mental arithmetic task (i.e., a psychological challenge) in the laboratory. Cardiovascular activity will be measured during a resting baseline period (10 minutes) and during the task (4 minutes). Participants will provide salivary samples before the task and after the task (\ 20-90 minutes) which will be used to assess neuroendocrine (i.e., cortisol) and inflammatory (i.e., IL-6). Cardiovascular, neuroendocrine, and inflammatory responses will be examined in relation to other study outcomes.
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-40 years * Identifying as American Indian * Living on or near Blackfeet reservation
Exclusion criteria
* Uncontrolled hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in systolic blood pressure activity from baseline to task | 10 minute resting baseline mean will be subtracted from the 4 minute task period for each value | The mean systolic blood pressure (mmHg) will be subtracted from the mean of the task period. |
| Changes in diastolic blood pressure activity from baseline to task | 10 minute resting baseline mean will be subtracted from the 4 minute task period for each value | The mean diastolic blood pressure (mmHg) will be subtracted from the mean of the task period. |
| Changes in heart rate activity from baseline to task | 10 minute resting baseline mean will be subtracted from the 4 minute task period for each value | The mean heart rate (bpm) will be subtracted from the mean of the task period. |
| Change in cortisol from baseline to task | Baseline will be subtracted from the peak (15 minutes after task onset, 35 minute task onset) | Salivary samples will be taken to measure cortisol (nmol/L) the mean from the peak stress period will be subtracted from the baseline |
| Changes in IL-6 from baseline to task | Baseline will be subtracted from the level 30 minutes after task onset. | IL-6 (pg/mL) measured at baseline will be subtracted from the IL-6 measured post task. |
| Pulse wave velocity | 5 minutes | Pulse wave velocity in m/s will be assessed by dual impedance cardiography as a non-invasive indicator of arterial stiffness. This measure will be derived from the 5 minute baseline period. |
| Resting systolic blood pressure | 10 minutes | Resting systolic blood pressure (mmHg) |
| Resting diastolic blood pressure | 10 minutes | Resting diastolic blood pressure (mmHg) |
| Inflammatory and anti-inflammatory cytokines | 5 minutes | Circulating levels of C-reactive protein, interleukin-6, tumor necrosis factor-a, monocyte chemoattractant protein-1, interleukin-1b, interleukin-10, and adiponectin will be assessed via a blood draw. A composite score will be created. |
| Hemoglobin A1c | 5 minutes | Hemoglobin A1c (nmol/L) will be assessed via blood draw |
| Glucose | 5 minutes | Glucose (nmol/L) will be assessed via blood draw |
| Insulin | 5 minutes | Insulin (mL) will be assessed via blood draw |
| Cholesterol | 5 minutes | Total cholesterol (mg) will be assessed via blood draw |
| Low-density lipoprotein | 5 minutes | Low-density lipoprotein (mg/dL) will be assessed via blood draw |
| High-density lipoprotein | 5 minutes | high-density lipoprotein (mg/dL) will be assessed via blood draw |
| Triglycerides | 5 minutes | Triglycerides (mmol/L) will be assessed via blood draw |
| Waist circumference | 2 minutes | Waist circumference |
| Hip circumference | 2 minutes | Hip circumference |
| Depressive symptomology (Hospital Anxiety Depression Questionnaire depression subscale) | 10 minutes | Hospital Anxiety Depression Questionnaire (depression subscale) |
| Depressive symptomology (PHQ-9) | 10 minutes | PHQ-9 |
| Anxiety symptomtology | 5 minutes | Hospital Anxiety Depression Questionnaire (Anxiety subscale) |
| Alcohol use | 10 minutes | Alcohol use will be assessed using the Alcohol Use Identification Test |
| Substance use | 5 minutes | A cumulative score of substance use will be reported by indicating the number of recreational drugs ever tried |
Countries
United States
Contacts
Primary ContactNeha John-Henderson, PhD
Backup ContactAnnie Ginty, PhD
Outcome results
None listed