Lateral Sclerosis
Conditions
Keywords
Scale
Brief summary
This is a national, multicentric, prospective, descriptive study evaluating the psychometric properties of the French version PLSFRS scale
Detailed description
This is a prospective study conducted in 8 French ALS centers which will enroll 80 patients with PLS. All these patients will undergo an evaluation of their functional status from the ALSFRS-r and PLSFRS scales. All patients will be evaluated at 3 time points (T0,M6 at the outpatient clinic) and at M3 remotely. The aim of the study will be to validate a trans-cultural and psychometric version of the PLSFRS available for the French PLS population.
Interventions
OTHERAssessment of the functional status
assessment of their functional status using the French version of the PLSFRS scale during a routine multidisciplinary assessment every 3-6 months for all patients with motor neurone disease, as recommended by the FILSLAN network
Sponsors
University Hospital, Tours
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with primary lateral sclerosis (PLS) * Age over 18 years * Informed consent signed * Patients cared in a French ALS centre
Exclusion criteria
* patients with no oral and written command of the French language * Patients unable to answer a questionnaire * Opposition to data processing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| French version of the PLSFRS scale | inclusion and 6 months | 10 items with a score from 0 to 6; 2 items with a score from 0 to 4 Maximal score is 68. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change Global Impression (CGI) scale | 6 months | overall clinical impression of the change; score from 1 to 7 |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORPhilippe CORCIA, PR
University Hospital, Tours
Outcome results
None listed