Assessment of Prognosis and Myocardial Reperfusion in Patients with ST-segment-elevation Myocardial Infarction (STEMI) According to Coronary Atherosclerotic Burden.

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06876974

Enrollment

2200

Registered

2025-03-14

Start date

2025-03-31

Completion date

2025-03-31

Last updated

2025-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

STEMI - ST Elevation Myocardial Infarction (MI)

Brief summary

In the current literature, it has been widely demonstrated that the extend of coronary atherosclerotic burden is associated with adverse long-term outcomes. Little is known about the impact of atheroma burden and either myocardial reperfusion and short-term outcomes after ST-segment elevation myocardial infarction (STEMI). Several angiographic scores have been used to measure the extend and severity of coronary atheroma. The SYNTAX score and the Gensini score have been shown to be independent predictors of cardiovascular events and mortality in stable coronary artery disease as well as in myocardial infarction. This research therefore aims to assess the impact of overall coronary atherosclerotic burden, measured by two angiographic scores (SYNTAX score and Gensini score), both before and after primary percutaneous angioplasty, in patients with STEMI according to different clinical subgroups.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- patients presenting with STEMI and treated with primary PCI (pPCI) at the University Hospital of Nancy between 2003 and 2023.

Exclusion criteria

\- patients with missing or incomplete coronary angiogram.

Design outcomes

Primary

Measure	Time frame	Description
All-cause mortality	2 years	all-cause mortality at 45 days, 1 year and 2 years
Recurrent acute coronary syndrome	1 year	Recurrent acute coronary syndrome at 1-year

Secondary

Measure	Time frame	Description
All-cause mortality in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock	2 years	All-cause mortality at 45 days, 1 year and 2 years in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock
Recurrent acute coronary syndrome in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock	1 year	Recurrent acute coronary syndrome at 1 year in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock

Outcome results