Long Covid-19
Conditions
Keywords
Covid-19
Brief summary
The study seeks to investigate the neurological effects caused by Covid-19 in children and adolescents in the 6-16 age group. To do this, neuropsychological scales, an EEG and an MRI were used.
Interventions
DIAGNOSTIC_TESTPsychological tests, EEG, Magnetic Resonance
Patients are administered some psychological tests, if they are positive they move on to the next stage, otherwise the patients leave the practice. If they are positive, EEG, MRI and other psychological tests are also administered.
Sponsors
Azienda Ospedaliero, Universitaria Pisana
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Age between 6 years and 16 years and 11 months * Symptomatology compatible with long neurological COVID, specifically: persistence or appearance of new neurological signs/symptoms (e.g. fatigue, headache, sleep disturbance, cognitive dysfunction, memory difficulties, emotional or mood disorders, vertigo cognitive dysfunction, memory difficulties, emotional or mood disorders, dizziness, dysautonomia, movement disorders movement disorders, ataxia, tremor, epilepsy, muscle weakness, myalgia, hyposmia, hypogeusia hearing loss or tinnitus and/or sensorimotor deficits such as hypoesthesia, dysesthesia) after three months after established SARS-CoV-2 infection, as well as persistence of these symptoms for at least two months, in the absence of a clear aetiology. * Signature of the appropriate Informed Consent by caregiver(s) and patient(s)
Exclusion criteria
* Poor knowledge of the Italian language or other limitation of verbal communication that compromises the subject's ability to perform neuropsychological tests * Need for sedation to perform brain MRI 7 Tesla * Neurological or neuropsychiatric disorder diagnosed prior to COVID-19 diagnosis * Caregiver's failure to sign consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cognitive and neuropsychological functions in children and adolescents with Long COVID between T0 and T1. | Test administration at the time of diagnosis of Long COVID (T0) and follow-up after 6-9 months (T1). | Assessment of cognitive, neuropsychological and adaptive skills in children and adolescents with Long COVID by means of standardised tests (WISC-IV, CPT3, NEPSY II, BRIEF-2, Vineland Adaptive Behavior Scales). The tests measure attention, memory, executive functions, intellectual-adaptive functioning and quality of life. |
Countries
Italy
Contacts
Primary ContactAlessandro Orsini, Dirigente medico
Outcome results
None listed