Craniopharyngioma, Endoscopic Pituitary Surgery, Meningioma, Olfactory Dysfunction, Pituitary Adenoma, Pituitary Disease
Conditions
Keywords
olfactory dysfunction, trigeminal dysfunction, endoscopic endonasal skull base surgery, pituitary surgery
Brief summary
In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.
Detailed description
The incidence of olfactory dysfunction following endoscopic endonasal skull base surgery remains unclear in current research, and the results vary widely. Additionally, the pathophysiology of this postoperative olfactory dysfunction and the impact of this surgery on the trigeminal system has not been investigated to date. In this study, the investigators developed a state-of-the-art clinical pipeline with olfactory and trigeminal assessments, prior to and following endoscopic endonasal skull base surgery. Furthermore, the investigators will collect surgical waste tissue from the posterior septal mucosa, which is removed during this procedure to gain access to the sphenoid sinus and the (para)sellar region. By performing histomolecular analysis, the research group aims to elucidate the pathophysiology of olfactory dysfunction following this surgery.
Interventions
PROCEDUREEndoscopic endonasal skull base surgery
This intervention will be performed as part of the standard-of-care for patients scheduled for endoscopic endonasal skull base surgery for lesions in the (para)sellar region
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients scheduled for endoscopic endonasal skull base surgery
Exclusion criteria
* Pre-existing anosmia * Patients has a history of previous endoscopic endonasal skull base surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of olfactory dysfunction | From enrollment to the last evaluation 6 months postoperatively |
| Incidence of trigeminal dysfunction | From enrollment to the last evaluation 6 months postoperatively |
| Etiology of olfactory and trigeminal dysfunction following endoscopic endonasal skull base surgery | Until the end of study (at 3 years) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors for olfactory dysfunction following endoscopic endonasal skull base surgery | From enrollment to the last evaluation 6 months postoperatively | Parameters such as smoking history, allergies, age, gender, co-morbidities will be investigated as possible covariates |
Countries
Belgium, Germany, Netherlands
Contacts
Primary ContactJulie van Waterschoot
Outcome results
None listed