Anorexia Nervosa, Bulimia Nervosa
Conditions
Keywords
resting state fMRI, longitudinal evaluation
Brief summary
The goal of this observational study is to learn if clinical and neurophysiological characteristics dynamics may follow similar trends in a longitudinal characterization of patients with a diagnosis of an eating disorder. The primary hypothesis is that the reversal of Functional Magnetic Resonance Imaging (fMRI) baseline alternations is positively associated with symptomatic amelioration. The secondary hypothesis is that the degree of (f)MRI baseline alternations is positively associated with symptoms. Participants will be asked to complete psychometric questionnaires, perform a fMRI and be recalled at 12 months for a follow-up.
Interventions
DIAGNOSTIC_TESTstructural and functional MRI
structural and functional MRI
Sponsors
Azienda Ospedaliero-Universitaria Careggi
Meyer Children's Hospital IRCCS
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
12 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Female sex * Age between 12 and 40 years old * Current diagnosis of Anorexia Nervosa or Bulimia Nervosa according to DSM-5-TR.
Exclusion criteria
* Previous or current diagnosis of schizophrenia or bipolar disorder, * Acute psychosis * Substance abuse * Severe medical comorbidities (hypercapnia, severe hypertension, cardiac arrhythmia, organ failure) * incapacity to grant written or verbal consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eating Disorder Inventory (EDI) psychometric score | Baseline - 12 months post-enrollment |
| Weight restoration | baseline - 12 months post-enrollment |
| Child Behavior Checklist (CBCL) score | Baseline - 12 months post enrollment |
| Children's Depression Inventory (CDI) score | baseline, 12 months post-enrollment |
| Multidimensional Anxiety Scale for Children (MASC) | Baseline - 12 months post-enrollment |
| Change in cortical thickness | baseline, 12 months post-enrollment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Regional Homogeneity (ReHo) index | baseline, 12 months post-enrollment | — |
| Chiange in amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF) of the blood oxygen-level dependent (BOLD) signal in fMRI data | baseline, 12 months post-enrollment | — |
| Change in connection degree between each node and other nodes (Degree of Centrality - DC) in the network in the brain. | Baseline - 12 months post-enrollment | — |
| Change of measure of interhemispheric connectivity between corresponding areas in fMRI (Voxelwise Homotopic Connectivity - VMHC) | baseline, 12 months post-enrollment | VMHC is a measure of interhemispheric connectivity between corresponding areas in fMRI. VMHC measures the level of symmetry, or correlation, between left/right pairs of voxels or brain areas. |
Countries
Italy
Contacts
Primary ContactTiziana Pisano
Backup ContactGiovanni Castellini
Outcome results
None listed