Endotracheal Intubation During Surgery, Optic Nerve Sheath Diameter
Conditions
Keywords
endotracheal intubation, optic nerve sheath diameter, lidocaine
Brief summary
This study aims to evaluate the effects of pre-intubation oropharyngeal topical lidocaine on optic nerve sheath diameter (ONSD) post-endotracheal intubation. The study will measure the ONSD using ultrasonography before intubation, and at 1, 5, and 10 minutes post-intubation. The results will be compared between patients receiving %10 lidocaine topically and %2 intravenous lidocaine.
Detailed description
Increased intracranial pressure (ICP) is a critical condition that requires early and accurate assessment. Traditional invasive ICP monitoring techniques, such as lumbar puncture and intracranial pressure monitoring devices, carry significant risks. Optic nerve sheath diameter (ONSD) measurement via ultrasonography is a non-invasive method that reflects increased ICP. Patients will be divided into two groups: Group A will receive %10 topical oropharyngeal lidocaine, and Group B will receive %2 intravenous lidocaine. The primary aim of the study is to evaluate the impact of lidocaine on ONSD at 1, 5, and 10 minutes post-intubation and to compare the effects on the two groups.
Interventions
DIAGNOSTIC_TESTOptic nerve sheath diameter measurement 0
optic nerve sheath diameter (ONSD) measured via ultrasonography before intubation
DIAGNOSTIC_TESToptic nerve sheath diameter measurement 1
optic nerve sheath diameter measurement 1 via ultrasonography after intubation 1st minute
DIAGNOSTIC_TESToptic nerve sheath diameter measurement 2
optic nerve sheath diameter measurement via ultrasonography after intubation 5th minute
DIAGNOSTIC_TESToptic nerve sheath diameter measurement 3
optic nerve sheath diameter measurement via ultrasonography after intubation 10th minute
PROCEDUREPre-intubation oropharyngeal topical %10 lidocaine
Pre-intubation oropharyngeal topical %10 lidocaine
PROCEDUREPre-intubation intravenous %2 lidocaine
Pre-intubation intravenous %2 lidocaine
Sponsors
Ankara City Hospital Bilkent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Double-blinded (Participants and Outcome Assessors)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA class I or II * Age 18-65 years * BMI 18-30 * No history or expected difficult intubation * No glaucoma or ocular pathology * No intracranial pressure increase
Exclusion criteria
* ASA class III and above * Obesity (BMI \> 30) * Difficult intubation history or risk * Glaucoma or other ophthalmic pathology * History of intracranial pressure increase or prior ophthalmic/intracranial surgery * Preoperative sedation * Active malignancy or ongoing radiotherapy/chemotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Optic nerve sheath diameter 0 | Before intubation | optic nerve sheath diameter (ONSD) measured via ultrasonography before intubation |
| Optic nerve sheath diameter 1 | 1 minute after intubation | optic nerve sheath diameter (ONSD) measured via ultrasonography 1 minute after intubation |
| Optic nerve sheath diameter 2 | 5 minutes after intubation | Optic nerve sheath diameter (ONSD) measured via ultrasonography 5 minutes after intubation |
| 0ptic nerve sheath diameter 3 | 10th minutes after intubation | 0ptic nerve sheath diameter (ONSD) measured via ultrasonography 10th minutes after intubation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative sore throat | 1 hour after recovery room admission | Postoperative sore throat is evaluated with Visual Analog scale |
Countries
Turkey (Türkiye)
Contacts
Primary Contactİsmail Aytaç, Ass. prof
Backup ContactDilan Yazar Doğan, resident
Outcome results
None listed