Preeclampsia
Conditions
Brief summary
Analysis of the circulating levels of placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia.
Detailed description
The aim of this study is to analyze the levels of circulating placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia to investigate the potential role of HLA-DR as early biomarker.
Interventions
Blood sampling in the first, second, trimester of pregnancy
Sponsors
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Pregnant Women * Aged \> 18 years
Exclusion criteria
* age \< 18 years * women unable to give informed consent * infectious diseases * twin pregnancies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Levels of circulating HLA-DR+ extracellular vesicles | During the first trimester of pregnancy (11-13 weeks +6 days of gestational age), the second trimester (19-22 weeks of gestation) and the third trimester (28-32 weeks of gestation) of pregnancy | Levels of circulating HLA-DR+ extracellular vesicles during pregnancy |
Countries
Italy
Outcome results
None listed