Eating Disorders, Mood Disorders in Children and Adolescents, Psychotic Disorder, QTc Intervals Changes
Conditions
Keywords
QTc interval, psychotropic drugs
Brief summary
Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal. Several psychotropic drugs are associated with an increased risk of QT prolongation, which is why in clinical practice a baseline ECG is performed before a psychotropic drug is prescribed. However, there are no validated protocols establishing when to repeat this examination or describing clinical events when this examination should be repeated in clinical follow-up. The study aims to investigate the incidence of QTc prolongation events as a side effect of chronic psychotropic drug administration. For this purpose, ECGs will be recorded and confounding factors of patients at the beginning of psychotropic therapy and after 3, 6 and 12 months will be analyzed.
Interventions
None listed
Sponsors
Meyer Children's Hospital IRCCS
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* Admitted to psychiatry ward * Starting a psychotropic drug acting on QT interval
Exclusion criteria
* Age \>18aa * History of administration of drug acting on QT interval in the 3 months prior
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in QT interval | Baseline, 1, 3, 6, 12, 18 months post- enrollment |
Secondary
| Measure | Time frame |
|---|---|
| Number of Cardiac events | Baseline, 1, 3, 6, 12, 18 months post- enrollment |
Countries
Italy
Contacts
CONTACTTiziana Pisano, MD
Outcome results
None listed