Serum CXCL10 and CRP Levels in Patients with Acne Vulgaris in Correlation with Disease Severity

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06869109

Acronym

CXCL10

Enrollment

Registered

2025-03-11

Start date

2025-03-10

Completion date

2026-04-10

Last updated

2025-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne Vulgaris

Keywords

acne vulgaris, cxcl10, crp

Brief summary

the correlations between CXCL10 levels, CRP, and acne severity scores (e.g., Global Acne Grading System) suggest that CXCL10 could serve as a biomarker of inflammation and acne severity. Understanding the relationship between CXCL10, CRP, and acne severity may offer insights into novel therapeutic strategies targeting inflammatory pathways in acne.

Detailed description

Cross-sectional Observational Study. using 4 groups a 3 of different acne severity and controle one . the serum cxcl10 and crp will measured in each patient to correlate with disease severity

Interventions

DIAGNOSTIC_TESTserum cxcl10

serum blood sample to measure the cxcl10

DIAGNOSTIC_TESTserum crp

blood sample to measure crp

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

12 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

1. Patients aged 12-40 years diagnosed with acne vulgaris. 2. Both genders included. 3. Patients with mild, moderate, or severe acne severity as determined by a validated scoring system (e.g., Global Acne Grading System). 4. Patients not on systemic acne treatment (e.g., isotretinoin or antibiotics) or anti-inflammatory drugs.

Exclusion criteria

1. Patients with autoimmune diseases, systemic illnesses, acute infection or any other chronic inflammatory conditions that may affect CRP or CXCL10 levels. 2. Pregnant or lactating individuals.

Design outcomes

Primary

Measure	Time frame	Description
Correlation of CXCL10 and CRP levels with acne severity (GAG score).	within one year after the result	compare the result of serum cxcl10 and crp with disease severity

Secondary

Measure	Time frame	Description
Identify thresholds of CXCL10 and CRP for predicting moderate/severe acne	within one year after the result	the least result to identify the group
Explore potential differences based on sex or age groups	within one year of the result	the effect of age and sex on the result

Countries

Egypt

Contacts

Primary ContactDina Essam, physician

dina.14224214@med.aun.edu.eg+201027664829

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026