Hypertension, Old Age
Conditions
Keywords
Blood pressure variability, Frailty
Brief summary
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) \<90 mmHg (or two episodes of daytime SBP \<90 mmHg, if mean 24 h SBP is \<125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events)
Detailed description
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) \<90 mmHg (or two episodes of daytime SBP \<90 mmHg, if mean 24 h SBP is \<125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events) Secondary objectives of the study: * To examine the association between home Blood Pressure Variability (BPV) and frailty, assessed using various tools for assessing frailty * To examine the association between short term BPV and adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events) * To determine the prevalence of hypotensive phenotype according to frailty status in hypertensive individuals.
Interventions
DIAGNOSTIC_TESTDiagnostic tests and questionnaires
Assessment of office blood pressure, orthostatic hypotension, 24-hour ambulatory blood pressure, frailty
Sponsors
Istituto Auxologico Italiano
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
75 Years to No maximum
Inclusion criteria
* Age ≥ 75 years * Diagnosis of hypertension according to the criteria of the European Society of Cardiology guidelines \[Williams 2018\] * Consent of the patient (or legal representative) to participate in the study
Exclusion criteria
* Refusal of the patient or his/her legal representative * Life expectancy of less than 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of adverse events | At 24 months of follow-up | Adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events) |
| Prevalence of hypotensive phenotype | At baseline | Hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) \<90 mmHg (or two episodes of daytime SBP \<90 mmHg, if mean 24 h SBP is \<125 mmHg) |
Countries
Italy
Contacts
CONTACTAlessandro Croce, MD
CONTACTLuca Grappiolo, Dr.
Outcome results
None listed