Cardiomyopathy
Conditions
Keywords
Cardiac amyloidosis
Brief summary
observational epidemiological study of patients affected by systemic amyloidosis
Interventions
None listed
Sponsors
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* patients diagnosed with amyloidosis or asymptomatic carriers of mutations in the transthyretin gene * minimum age of 18 years at the time of diagnosis * obtaining informed consent
Exclusion criteria
* nothing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of amyloidosis | throughout the study period until 10 years | prevalence of amyloidosis in patients admitted to the UOs participating in the study |
| incidence of amyloidosis | throughout the study period until 10 years | incidence of amyloidosis in patients admitted to the UOs participating in the study |
| Observational epidemiological study of patients with systemic amyloidosis | throughout the study period until 10 years | characteristics of each etiology in terms of baseline clinical data |
| Types of cardiac clinical phenotype | throughout the study period until 10 years | Cardiac clinical phenotype in patients who at baseline are asymptomatic carriers of pathogenic mutations |
| Incidence of mixed clinical phenotype | throughout the study period until 10 years | Mixed clinical phenotype in patients who at baseline are asymptomatic carriers of pathogenic mutations |
| Incidence of hospitalization for heart failure | throughout the study period until 10 years | Incidence during follow-up of hospitalization for heart failure |
| Incidence of hospitalization for onset of arrhythmias | throughout the study period until 10 years | Incidence during follow-up of hospitalization for onset of arrhythmias |
| Incidence of hospitalization for stroke | throughout the study period until 10 years | Incidence of hospitalization for stroke during follow-up |
| incidence of pacemaker implantation | throughout the study period until 10 years | incidence during follow-up of need for pacemaker implantation |
| incidence of pacemaker implantation of defibrillator | throughout the study period until 10 years | incidence during follow-up of need for defibrillator implantation |
| Incidence of cardiac transplantation | throughout the study period until 10 years | incidence during follow-up of need for cardiac transplantation |
| Incidence of transplantation of other solid organs | throughout the study period until 10 years | incidence during follow-up of need for other solid organ transplantation |
| Mortality | throughout the study period until 10 years | total mortality during follow up |
Countries
Italy
Contacts
Primary Contactsimone longhi, MD
Outcome results
None listed