Female, Postmenopausal
Conditions
Keywords
Kidney Health, Post-Menopause, Heat Stress, Hydration, Older Adults, Aging, Postmenopausal Women
Brief summary
The investigators are assessing how seasonal changes affect kidney function biomarkers in post-menopausal women, an understudied group. While heat stress can reduce kidney function, previous research has not accounted for physical activity, diet, hydration, or sun exposure.
Detailed description
Intense heat stress on the body can reduce kidney function. A recent study reported that blood markers of kidney function are lower among people in hotter climates. However, these data did not consider physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight. Therefore, the investigators invite participants to help determine whether there are seasonal changes in kidney function biomarkers. This will also help the investigators understand if physical activity, food intake, fluid intake, time spent outdoors, or exposure to sunlight affect kidney function biomarkers between seasons. The investigators are studying female adults post-menopause since they are an understudied group.
Interventions
This research focuses on examining seasonal variations in kidney function among postmenopausal females. As an observational study, our approach is non-interventional.
Sponsors
Florida State University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Female aged ≥55 years old * Self Reported as at least one year post-menopause * Live in Tallahassee, Florida, or the surrounding area
Exclusion criteria
* Have a BMI of ≥30 kg/m2 * Systolic blood pressure of ≥140 and/or diastolic blood pressure ≥90 mmHg * Self Reported Current or recent (regular use within the past six months) use of a diuretic medication * Self Reported: Uncontrolled cardiovascular, respiratory, neurological, renal, liver, or metabolic health condition * Current or recent (regular use within the past six months) use of tobacco, nicotine, nonsteroidal anti-inflammatory products * No regular (≥once per week) purposeful heat exposure (e.g., sauna, spa, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma neutrophil gelatinase-associated lipocalin (NGAL) | Visit 1 (0 months) and Visit 2 (7 months) | Changes in NGAL will be measured in blood samples using enzyme-linked immunosorbent assay. |
| Urinary neutrophil gelatinase-associated lipocalin (NGAL) | Visit 1 (0 months) and Visit 2 (7 months) | Changes in NGAL will be measured in urine samples using radioimmunoassay. |
| Insulin-like growth factor-binding protein 7 (IGFBP7)*Tissue inhibitor of metalloproteinase-2 (TIMP-2) | Visit 1 (0 months) and Visit 2 (7 months) | The product of Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2) will be measured in blood samples using enzyme-linked immunosorbent assays. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| estimated glomerular filtration rate (eGFR) | Visit 1 (0 months) and Visit 2 (7 months) | eGFR will be calculated from creatinine using CKD-EPI equation. |
Countries
United States
Outcome results
None listed