Alcohol Use Disorder, Postoperative Complications
Conditions
Keywords
alcohol consumption, surgical outcomes
Brief summary
This study aims to see if there's a link between a substance called phosphatidylethanol (PEth) and how patients who have surgery at University Hospitals do after surgery. PEth levels reflect the amount of alcohol use by someone over the past few weeks. This study is checking PEth levels on all patients who are planned to stay in the hospital for three or more days after surgery regardless if they drink alcohol. Specifically, it will look at if PEth levels are connected to problems that might come up during and after surgery, like confusion, lung or heart issues, needing blood transfusions, infections, unexpected intensive care unit (ICU) stays, and longer hospital stays. While there are reports of moderate alcohol consumption being good for the heart, there are other data that alcohol consumption can be harmful. Since there's not much information on how drinking alcohol affects health outcomes during and after surgery, especially for patients who are planned to be admitted to the hospital ward or ICU after surgery, this study will hopefully see if PEth levels before surgery can predict how patients do after the surgery. The inclusion criteria to only include patients who consume alcoholic beverages was an IRB approved modification after already recruiting 1/3 of patients.
Interventions
OTHERBlood Draw
Patients will have a single blood sample sent for PEth testing, blood draws will happen during standard of care blood draw.
Sponsors
University Hospitals Cleveland Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* 1\. Age range: 21-79 * 2\. Patients undergoing elective surgery at UHCMC with planned ICU admission * 3\. Patients undergoing elective surgery at UHCMC with expected in-hospital admission for three or more days * 4\. Only patients who consume alcoholic beverages on a regular basis.
Exclusion criteria
* 1\. Patients undergoing same day outpatient surgeries or expected to be admitted less than three days post-operatively * 2\. Subjects who have received a blood transfusion within the past month before surgery * 3\. Pregnant subjects
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Phosphatidylethanol level as measured by blood draw. | Baseline | — |
| Length of ICU stay measured in days | Up to 7 days | — |
| Length of hospital stay measured in days | Up to 2 weeks | — |
| Number of perioperative complications as measured by medical record review. | Up to six months | Perioperative complications including but not limited to delirium, pulmonary complications, cardiovascular complications, need for transfusion including amount transfused, post-operative infections, unexpected admission to the intensive care unit (ICU) and increased length of stay |
Countries
United States
Contacts
CONTACTAyse Ulucay, MD
PRINCIPAL_INVESTIGATORSalim Hayek, MD, PhD
University Hospitals
Outcome results
None listed