Binge-Eating Disorder, Emotional Eating, Healthy Volunteers
Conditions
Keywords
Binge-Eating Disorder, Emotion regulation, fNIRS, Prefrontal cortex, Eating disorder, Emotional Eating
Brief summary
The goal of this exploratory, interventional, multicentre study is to compare the prefrontal activity during a negative emotion regulation task in women with Binge-Eating Disorder (BED) and healthy women with and without Emotional Eating (EE). The aim of this study is to compare the prefrontal processing of cognitive control of emotions between BED and EE and to compare the emotional processing and emotional experience between BED and EE. The study will thus compare four experimental groups: patients with BED, BMI-matched healthy volunteers with EE, BMI-matched healthy volunteers, and healthy volunteers of normal weight without BED. Participants will perform a down-regulation task of negative emotions elicited by negative pictures. During this task, their cerebral activity will be recorded using functional near-infrared spectroscopy (fNIRS), as well as their autonomous activity (skin conductance, pulse rate, respiration rate).
Interventions
BEHAVIORALEmotion regulation task (fNIRS recording during the emotional regulation task)
No drugs were used in this study. All participants perform an emotion regulation task. More precisely, they have to down regulate negative emotions elicited by negative pictures using a cognitive reaprasal strategy. To this end, they have to change the meaning of the picture they are watching in order to decrease motional intensity.
Sponsors
INSERM UMR 1322 LINC
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
It is important to note that no drugs are tested. The task (emotion regulation) is consistent for all groups.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Women between 18 and 60 years old (including 60) * Right-handed. * For patients only : diagnosed with Binge Eating Desordors according to DSM criteria. * Membership of a French social security scheme or beneficiary of such a scheme. * Non-opposition of the subject to participate in the study. Non inclusion Criteria: Healthy volunteers only : * Suffering from an eating disorder or any other psychiatric disorder. * History of bariatric surgery. All subjects (healthy volunteers and patients) : * Rare obesity (genetic or syndromic). * Specific addictions (substances or behaviors). * Neurological disorders and/or history of stroke or head trauma. * Presence of lesions, wounds or dermatitis at the sites where the recording devices are applied. * Any serious acute or chronic illness other than the pathology under study, or any treatment likely to interfere with the evaluation of the parameter under study. * Inability to follow protocol requirements. * Subject unlikely to cooperate with the study and/or poor cooperation anticipated by the investigator. * Subject unable to speak French and/or unable to read. * Pregnant or breast-feeding women. * Persons deprived of their liberty by judicial or administrative decision; persons under compulsory psychiatric care; persons admitted to a health or social institution for purposes other than research.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of prefrontal cortex activity using functional near-infrared imaging (fNIRS). | Day 1 during the viewing of images with negative valence | The fNIRS signal represents the concentration of oxyhemoglobin and deoxyhemoglobin over time. It provides information about the local oxygen demand of the brain and therefore its activity. It is these concentrations during the regulatory task that are used as the primary outcome measure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psychophysiological measurements: electrodermal activity | Day 1 during the viewing of images with negative valence | Skin conductance measures are recorded These provide information on the autonomic nervous system (sympathetic and parasympathetic) and thus on emotional processing and arousal. |
| Psychophysiological measurements: electrocardiogram | Day 1 during the viewing of images with negative valence | Electrocardiogram measures are recorded These provide information on the autonomic nervous system (sympathetic and parasympathetic) and thus on emotional processing and arousal. |
| Psychophysiological measurements: respiratory rate | Day 1 during the viewing of images with negative valence | Respiratory rate is recorded These provide information on the autonomic nervous system (sympathetic and parasympathetic) and thus on emotional processing and arousal. |
Countries
France
Contacts
Primary ContactBILLOT Pierre-Edouard, PhD
Backup ContactPOZET Astrid
Outcome results
None listed