Ageing, Cognitive Impairment, Disability, Frailty, Intrinsic Capacity
Conditions
Keywords
Ageing, Disability, Cognitive Impairment, Community, Cohort
Brief summary
The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for disability and cognitive impairment among community-dwelling adults aged 65 years and over. The main question it aims to answer is: * What are the high-risk factors able to predict the incidence and advance of disability and cognitive impairment in community-dwelling adults aged 65 years and over? * What are the categories of function and cognitive performance trajectory in community-dwelling adults aged 65 years and over?
Detailed description
BLINDSCE is a community-based prospective cohort study that includes individuals aged 65 and over from urban and rural areas in Beijing. Participants will provide detailed demographic information and undergo multifactorial questionnaires, disability measurements, cognitive assessments, other disability-related outcomes, and clinical biochemical measures. The study has started recruitment and enrollment in 2023 and will follow-up once every 1-2 year. This work consists of three steps as follows. First, by collecting baseline and follow-up data of participants, we plan to establish a community-dwelling elderly database in Beijing. Second, high-risk factors can be pre-screening based on this cross-sectional analysis. Third, longitudinal data was used to develop the prediction model and trajectory analysis for disability and cognitive impairment.
Interventions
None listed
Sponsors
Beijing Municipal Health Commission
Xuanwu Hospital, Beijing
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Community-dwelling adults aged 65 years or older who reside in Beijing. * Participants who sign an institutionally approved informed consent.
Exclusion criteria
* Participants with severe mental disorders and serious medical conditions preventing study investigation * Participants undergoing long-term professional treatment for physical function and cognitive functioning, such as hospitalization or rehabilitation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disability from the individual's perspective | An average of 1 to 2 years | Disability is assessed using the 12-item World Health Organization's Disability Assessment Schedule 2.0 (WHODAS 2.0). The WHODAS 2.0 is a patient-reported disability measure, comprising six life domains involving cognition, mobility, self-care, interpersonal relationships, life activities, and participation. The total score of 12-item WHODAS 2.0 categorizes disability from no disability (score 0) to complete disability (score 48). |
| Disability from the medical's perspective | An average of 1 to 2 years | Disability is assessed using the basic activities of daily living (BADL) scale, the Katz Index scale. The minimum value is 0 , and the maximum value is 6. The higher the score, the better the outcome. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intrinsic capacity | An average of 1 to 2 years | Intrinsic capacity is the composite of physical and mental abilities that an individual can draw upon. It comprises locomotor, sensory (hearing and vision), vitality, psychological, and cognition domains. The intrinsic capacity composite score is used to assess intrinsic capacity. The intrinsic capacity composite score ranges from 0 to 100, and the higher the score, the better the outcome. |
| Frailty | An average of 1 to 2 years | Frailty is assessed using the Fried frailty phenotype (FFP) scale. The minimum value is 0, and the maximum value is 5. The higher the score, the worse the outcome. |
| Hospitalization | An average of 1 to 2 years | Hospitalized times, duration, diagnosis, surgery, bedridden status, assisted ventilation treatment, catheter treatment are collected by questionnaire and supplemented through a review of electronic medical records. |
| Death | An average of 1 to 2 years | The date and cause of death are collected from the participant's family members/healthcare providers and supplemented through a review of electronic medical records. |
| Cognitive impairment | An average of 1 to 2 years | The cognitive impairment is assessed by the Mini-Mental State Examination (MMSE). The minimum value is 0, and the maximum value is 30. The higher the score, the better the outcome. |
| Muscle strength | An average of 1 to 2 years | Muscle strength is assessed by the grip strength. The higher the value, the better the outcome. |
| Physical performance | An average of 1 to 2 years | Physical performance is assessed by the Short Physical Performance Battery (SPPB) test. The minimum score is 0, and the maximum score is 12. The higher the score, the better the outcome. |
| Sarcopenia | An average of 1 to 2 years | Sarcopenia is screened by the SARC-F scale. The minimum value is 0, and the maximum value is 10. The higher the score, the worse the outcome. |
| Appendicular skeletal muscle mass | An average of 1 to 2 years | Appendicular skeletal muscle mass (ASM) is estimated using a physical measurement formula. Weight in kilograms, height in centimeters, gender(male or female), and age in years are combined to report ASM through the formula: ASM = 0.193\*weight(kg) + 0.107\*height(cm) - 4.157 \* gender - 0.037\*age(year) - 2.631. The higher the value, the better the outcome. |
| Subjective cognitive decline | An average of 1 to 2 years | Subjective cognitive decline is assessed by the subjective cognitive decline questionnaire-9 items (SCD9). The minimum value of SCD9 is 0, and the maximum value is 9, the higher the score, the worse the outcome. |
Countries
China
Contacts
Primary ContactYansu Guo, Ph.D
Outcome results
None listed