Brain Tumor
Conditions
Keywords
brain tumor, postoperative delirium
Brief summary
1. To explore whether the combined administration of dexmedetomidine during and after surgery in patients undergoing brain tumor resection is an effective and safe modality to prevent postoperative delirium and improve sleep quality than giving it alone after surgery. 2. To explore whether intraoperative and postoperative administration of dexmedetomidine to patients undergoing brain tumor surgery can reduce postoperative acute pain and prevent chronic pain. 3. To explore whether intraoperative and postoperative administration of dexmedetomidine to patients undergoing brain tumor surgery can provide stable anesthesia depth, hemodynamics and reduce the dose of anesthetics, thereby accelerating patient recovery.
Interventions
DRUGDexmedetomidine
During the surgery, target-controlled infusion (TCI) pumps were used, employing the Dyck model for continuous infusion of propofol, with the target plasma concentration maintained at 0.2 ng/ml. Postoperatively, propofol was infused at a rate of 0.2-0.4 mcg/kg/hr according to the intensive care unit's protocol, until the patient had the endotracheal tube removed.
DRUGNormal Saline
During the surgery, equal volumes of saline were injected. After the surgery, the patient was transferred to the intensive care unit, where propofol was continuously infused at a rate of 0.2-0.4 mcg/kg/hr according to the ICU protocol, until the endotracheal tube was removed.
Sponsors
Kaohsiung Medical University Chung-Ho Memorial Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* at least 18 years old and less than 80 years old * receive brain tumor surgery with ASA II\ III.
Exclusion criteria
* under the age of 18 or over 80 * consciousness unclear * those who have not signed a consent form * those with high anesthesia risk ASA IV or higher
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment and Documentation of Delirium | Perioperative | Confusion assessment method in intensive care unit using questionnaire(CAM-ICU), The evaluation method is yes or no, with no being the best. |
Countries
Taiwan
Contacts
Primary ContactZhi-Fu Wu
Outcome results
None listed