Crohn Disease (CD), Juvenile Idiopathic Arthritis (JIA), Ulcerative Colitis (UC)
Conditions
Keywords
JIA, Dietary habits, CD, UC, IBD
Brief summary
The proposed study is part of a PNRR 2022 project (call Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems, currently awaiting funding response) and represents the continuation of an observational clinical study named TRANSMIC, approved by the pediatric ethics committee of the Tuscany region. TRANSMIC was an integral part of a European research project within the joint programming initiative (JPI), under the HDHL-INTIMIC theme: A Healthy Diet for a Healthy Life, aimed at understanding the cause-effect relationships between diet, gut microbiome, and human health. Understanding the role of diet in inflammatory bowel diseases (IBD) and exploring its role in autoimmune inflammatory conditions with joint manifestations, such as JIA, provides additional insights into the development, progression, and management of these conditions, opening new horizons for the use of dietary treatments in preventing these inflammatory conditions.
Interventions
OTHERCollecting questionnaires and biological samples
For each family member will be collected a 3-days food diary, a food frequencies questionnaire and a questionnaire assessing the adherence to the mediterranean diet. Additionally, a blood sample for trascriptomic analysis and a fecal sample for gut microbiota analysis will be collected
Sponsors
Meyer Children's Hospital IRCCS
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
For families with at least one child/adult affected by IBD/JIA: * Father and mother with children aged between 0-18 years, in good health. * At least one adult or one child affected by IBD, or a child affected by JIA, regardless of ongoing therapy and without distinction of disease severity or activity. For healthy families: \- Father and mother with children aged between 0-18 years, in good health and not affected by chronic inflammatory bowel diseases or chronic autoimmune inflammatory diseases in general.
Exclusion criteria
For subjects affected by IBD: * Monogenic disease * Children with an ileostomy or who have undergone a colectomy For subjects affected by JIA: \- No
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-days food diary, kidmed and medi-lite scores | After two weeks |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of families with microbiota alteration | After 6 months |
Countries
Italy
Contacts
Primary ContactPaolo Lionetti, MD, PhD, Ordinary Professor
Outcome results
None listed