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Arteriovenous Fistula Pain and Cold Application

The Effect of Cold Application Using Two Different Methods on Arteriovenous Fistula Pain

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06862687
Enrollment
48
Registered
2025-03-06
Start date
2024-05-01
Completion date
2024-12-01
Last updated
2025-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arteriovenous Fistula Pain

Keywords

Arteriovenous Fistula, cold application, Hemodialysis, Kidney Failure, Pain

Brief summary

TThis study was designed as a single-group comparative prospective intervention study. The aim of the study was to assess the effectiveness of different pain management interventions during AVF cannulation. The effects of pain management methods such as cooling spray, aloe vera gel, and the standard procedure on pain levels, and which intervention was more effective in reducing pain compared to the standard procedure, were investigated. The study included patients over 18 and under 65 years old, undergoing hemodialysis, having an AVF, literate, without an aloe vera allergy, and without communication barriers or psychiatric disorders. The main research questions were defined as follows: Did different pain management methods (cooling spray, aloe vera gel, and standard procedure) affect pain levels during AVF cannulation? Which intervention was more effective in reducing pain levels? The primary hypotheses were defined as The application of cooling spray and aloe vera gel would reduce pain levels more than the standard procedure. The researchers compared pain levels after each intervention to determine which one was more effective. Three different interventions (cooling spray, aloe vera gel, and standard procedure) were applied to participants in sequence, and pain levels were assessed after each intervention using the Visual Analog Scale (VAS). Additionally, feedback from participants regarding each intervention was collected.

Interventions

OTHERCooling Spray

A cooling spray containing propan-butane-pentane was applied 25 cm from the cannulation site until mild whitening/frosting appeared. The standard AVF cannulation procedure was performed. Pain levels were measured immediately after the procedure using VAS.

OTHERCold Aloe Vera Gel Application

1 ml of cold aloe vera gel was applied to a 5x5 cm area over the fistula site. The standard AVF cannulation procedure was conducted. Pain levels were assessed post-procedure using VAS.

OTHERStandard Procedure (Control Condition)

No additional pain-relief intervention was applied. The nurse performed the standard AVF cannulation procedure, including hand hygiene, thrill assessment, and site disinfection. Pain levels were assessed immediately after cannulation using the Visual Analog Scale (VAS).

Sponsors

Ataturk University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Over 18 and under 65 years old * Literate * Have an arteriovenous fistula (AVF) * Undergoing hemodialysis (HD) treatment at least twice a week * No allergy to aloe vera * No communication barriers and/or psychiatric disorders

Exclusion criteria

* Diagnosed with malignancy * Having any sensory problems that prevent the assessment of perception and pain * Using any analgesic preparations * Having a vascular access other than AVF * Patients in whom AVF cannulation is not successful in a single attempt

Design outcomes

Primary

MeasureTime frameDescription
Pain Level (VAS - Visual Analog Scale)3 monthsThe pain level experienced by patients after AVF cannulation was assessed using the VAS (0-10 scale). Pain scores were recorded and compared across all three interventions. Lower VAS scores indicate greater effectiveness of the intervention in pain reduction. n this scale, patients are asked to describe their pain using numbers, where 0 represents no pain and 10 indicates the highest, unbearable pain.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026