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The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients

The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06861764
Enrollment
8000
Registered
2025-03-06
Start date
2020-04-01
Completion date
2022-04-30
Last updated
2025-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cohort Studies

Keywords

preoperative anxiety, Aged, postoperative delirium

Brief summary

This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the the relationship between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort

Detailed description

This is a retrospective cohort study using prospective data from a multicenter database. 8000 elderly patients undergoing elective non-cardiac or non-neurosurgical surgery were included in this study. The Generalized Anxiety Disorder Scale (GAD-7) was used to measure preoperative anxiety symptoms. The confusion assessment method (3D-CAM) was used to assess postoperative delirium in elderly patients undergoing non-cardiac surgery. If the patient is discharged, follow up by phone or email. Binary logistic regression analysis and propensity score matching (PSM) and subgroup analysis were used to analyze the data.

Interventions

None listed

Sponsors

Beijing Tiantan Hospital
CollaboratorOTHER
Peking University First Hospital
CollaboratorOTHER
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
CollaboratorOTHER
Xiangya Hospital of Central South University
CollaboratorOTHER
Beijing Anzhen Hospital
CollaboratorOTHER
Central South University
CollaboratorOTHER
Peking University People's Hospital
CollaboratorOTHER
Zhejiang University
CollaboratorOTHER
Fudan University
CollaboratorOTHER
Sun Yat-sen University
CollaboratorOTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
CollaboratorOTHER
China-Japan Friendship Hospital
CollaboratorOTHER
The Affiliated Hospital Of Guizhou Medical University
CollaboratorOTHER
First Affiliated Hospital of Xinjiang Medical University
CollaboratorOTHER
First Affiliated Hospital of Guangxi Medical University
CollaboratorOTHER
Taihe Hospital
CollaboratorOTHER
Zhejiang Provincial People's Hospital
CollaboratorOTHER
Shanghai Zhongshan Hospital
CollaboratorOTHER
Chinese PLA General Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
65 Years to 100 Years
Healthy volunteers
Yes

Inclusion criteria

* elderly patients (age ≥ 65 years) * non-cardiac surgery, non-neurosurgical surgery

Exclusion criteria

* History of neurological or psychiatric disorders or use of neuropsychiatric drugs; * Impaired cognitive function or inability to cooperate with preoperative follow-up; * Sent to ICU after surgery; * Deletional delirium outcome; * Baseline missing \>5%

Design outcomes

Primary

MeasureTime frameDescription
Postoperative deliriumwithin 7 days after surgeryThe incidence of postoperative delirium was assessed by a 3-minute diagnostic interview in the surgical ward (3D-CAM).

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026