The Effect of Norepinephrine on the Development of Pressure Injury

The Determination of the Effect of Norepinephrine Infusion on the Development of Pressure Injury Among Critically Ill Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06860308

Enrollment

289

Registered

2025-03-06

Start date

2024-12-01

Completion date

2025-02-20

Last updated

2025-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pressure Injury

Keywords

pressure injury, norepinephrine, vasopressor, intensive care, development

Brief summary

Norepinephrine mainly increases mean arterial pressure among intensive care patients. It may be an essential risk factor in developing pressure injuries. However, there are still conflicting findings in the literature. This study aimed to examine the effect of norepinephrine infusion on the development of pressure injuries among patients in adult intensive care. This retrospective and correlational study was conducted between March 2021- May 2022. The electronic patient data were obtained from 289 adult patients (Case group n=149; control group n=149) treated with and without norepinephrine in the intensive care unit, respectively. The demographic and clinical characteristics were evaluated using descriptive statistical methods (number, percentage, mean, standard deviation). A logistic regression model was established to estimate the dependent variable (development of pressure injury) with the independent variables.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

The sample consisted of all patients * over 18 years old * who did not have pressure injuries upon admission to the intensive care unit. Patients who received norepinephrine and received norepinephrine infusion for at least 48 hours during their stay in ICU were included in the case group (n=149), and patients who did not receive an infusion were included in the control group (n=140).

Exclusion criteria

The sample excluded of all patients * less than 18 * who have pressure injuries during admission * who had norepinephrine infusion less than48 hours during their stay in the intensive care unit.

Design outcomes

Primary

Measure	Time frame	Description
development of pressure injury after admission to intensive care unit until discharge	after admission of patients to the intensive care unit until discharge between from March 2021 to May 2022. .	The development of pressure injuries after admission of patients to the intensive care unit until discharge between from March 2021 to May 2022. . This is a retrospective study, so there is no specific time. We specified time frame details below.

Countries

Turkey (Türkiye)

Outcome results