Adhesive Peritoneal Band
Conditions
Keywords
adhesions, corticosteroids, fresh frozen plasma
Brief summary
Adhesive Intestinal obstruction is an inevitable complication of abdominal surgery with significant morbidity associated with poor quality of life and predispose to repeated hospitalization. Most of them (73% - 90%) can be managed conservatively.Despite advances in surgery, 15to 30% require surgical intervention primarily or due to failure of conservative management. Because of the nature of the disease recurrence has been estimated to be 30%.Many attempts to prevent formation of postoperative adhesions have been tried. In this trial, we will study the effect of corticosteroids and FFP in prevention of adhesive small bowel obstruction recurrence for follow up of 2 years duration.
Interventions
PROCEDUREintra-abdominal instillation of corticosteroids
after adhesiolysis, peritoneal lavage with diluted corticosteroids will be instillated intra-abdominally
PROCEDUREintra-abdominal instillation of fresh frozen plasma
after adhesiolysis, peritoneal lavage with diluted FFP will be instillated intra-abdominally
Sponsors
Zagazig University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with attacks of adhesive intestinal obstruction
Exclusion criteria
* Associated abdominal malignancy, patients with adhesive IO who respond to conservative treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| intestinal obstruction | from 1 day to 2 years post operative | intestinal obstruction is detected if the patient had constipation and vomiting with ultrasound showing dilated bowel and to and fro movement and the plain erect shows multiple air fluid levels |
| bowel injury | from 1 day to 2 years post operative | bowel injury will be detected if intestinal contents present in the drain or wound |
| wound infection | from 1 day to 2 weeks post-operative | wound infection is detected if there is pus in the drain or wound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| age | from 2 to 3 days before surgery | age will be recorded in years |
| sex | from 2 to 3 days before surgery | The sex of the patient will be recorded (male or female) |
Countries
Egypt
Outcome results
None listed