Postoperative Pain, Acute
Conditions
Brief summary
Vitamin C, also known as ascorbic acid, is a potent reducing agent and antioxidant that plays a crucial role in various metabolic processes.Vitamin B complex, a group of eight essential B vitamins, plays a crucial role in cellular metabolism, energy production, and maintaining nervous system health. There are few available studies on the effects of vitamin B injection on plasma inflammatory markers and its adjuvant analgesic effect along with the routine multimodal analgesia. Considering limited research and existing controversies in this field, the aim of present study is to evaluate the effects of preoperative and intraoperative vitamin B12 administration compared to vitamin C when used as a component of the multimodal analgesic technique in patients undergoing laparoscopic cholecystectomy.
Interventions
group of vit. B will recieve as an oral capsules for 4 days preoperative , and infusion of vitamin B complex 1ml diluted in 100 ml normal saline administered intravenously after anathesia induction .
DRUGvitamin C
group of vitamin C will recieve 1000 mg as an oral capsule for 4 days and infusion at dose of 50 mg/kg diluted in 100 ml normal saline administered iv after induction of anathesia .
DRUGPlacebo
patients will recieve placebo tablets with identical regimen preoperative and a placebo infusion of 100 ml normal saline after induction of anathesia ,prepared with identical appearance and taste by the pharmacist according to the randomization group.
Sponsors
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Adult patients (age 18-60 years) * American Society of Anesthesiologists (ASA) classification I-II * Patients undergoing laparoscopic cholecystectomy under general anaesthesia
Exclusion criteria
* Hypersensitivity to vitamin B complex or vitamin C * History of chronic pain or use of opioids within the last month * Patient with inflammatory conditions * Severe renal or hepatic impairment * Patient with intellectual disabilities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total dose of analgesics required postoperatively | within the first 24 hours and the time to first request |
Countries
Egypt
Contacts
Primary ContactIslam M Hosainy, Master
Outcome results
None listed