Skip to content

The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading

The Immediate Physiological and Perceptual Response to Blood-flow Restricted Strength Training With Eccentric Loading (E-BFR): a Randomised Crossover Study in Healthy Subjects

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06856629
Acronym
E-BFR
Enrollment
48
Registered
2025-03-04
Start date
2025-01-31
Completion date
2025-07-28
Last updated
2025-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Blood-flow restriction training, acute physiological response, eccentric training

Brief summary

Decreasing workloads in strength training makes it more tolerable for a broad range of people. When designed as blood-flow restriction training, similar gains in strength and muscle mass are achieved compared to traditional training. Adding high training loads to blood-flow restriction training only in the eccentric phase (BFR-ECC) might achieve superior gains in muscle strength while still maximizing tolerability of the training stimuli. This study aims to investigate the acute physiological and perceptual response of blood-flow restriction training with eccentric loading in comparison to traditional eccentric training. The study recruits healthy individuals ≥ 18 years.

Interventions

OTHEREccentric blood-flow restriction training

Eccentric blood-flow restriction training

OTHEREccentric free-flow training

Eccentric free-flow training

Sponsors

Dario Kohlbrenner
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE

Intervention model description

With random sequence allocation

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Clinically Healthy

Exclusion criteria

* Physical or intellectual impairment precluding informed consent or protocol adherence * Pain during exercise of any origin * History of thromboembolic event in the lower extremity * Known pregnancy (no testing is carried out)

Design outcomes

Primary

MeasureTime frameDescription
minute ventilationDuring the intervention (i.e., exercise) for 10 minutesrecorded with breath-by-breath analysis

Secondary

MeasureTime frameDescription
Other variables from breath-by-breath analysisDuring the intervention (i.e., exercise) for 10 minutesVO2, VCO2, RER, breath rate, heart rate
Rate of perceived exertionImmediately after the intervention (i.e., exercise)Numeric rating scale from 0-10. Participants rate perceived leg exertion and perceived respiratory exertion
Near-infrared spectroscopy of the vastus lateralisDuring the intervention (i.e., exercise) for 10 minutesTissue saturation
Delayed onset muscle soreness24, 48, and 72 hours after each of the intervention (i.e., exercise)Numeric rating scale 0-10 rating intensity of DOMS symptoms
Feasibility and tolerabilityAfter study completion (i.e., after the second study visit, up to 2 weeks)Custom-made questionnaire

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026