Appendectomy, Appendicitis With Perforation, Probiotic
Conditions
Keywords
Perforated Appendicitis, Appendectomy, Probiotic, Laparotomy
Brief summary
Does the administration of the probiotic Lactobacillus plantarum sp. have an impact on reducing leukocyte levels, segmented neutrophil counts, postoperative pain, and length of hospitalization in patients with diffuse peritonitis caused by perforated acute appendicitis who underwent laparotomy appendectomy at Dr. Hasan Sadikin Hospital?
Detailed description
To determine whether the administration of the probiotic Lactobacillus plantarum sp. to patients with diffuse peritonitis caused by appendiceal perforation undergoing laparotomy appendectomy at Hasan Sadikin Hospital Bandung and Siloam Karawaci Hospital has a significant effect on leukocyte levels, segmented neutrophil counts, postoperative pain levels, and length of hospitalization compared to the placebo group.
Interventions
DIETARY_SUPPLEMENTLactobacillus plantarum sp Probiotic
Once daily consumption
OTHERPlacebo Group
Group who received a placebo intervention
Sponsors
Universitas Padjadjaran
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with diffuse peritonitis caused by appendicitis * Patients undergoing laparotomic appendectomy. * Patients aged 18 years or older.
Exclusion criteria
* Patients with a history of previous laparotomy. * Patients who underwent laparotomy combined with surgery on other parts of the body. * Patients with a history of cancer. * Patients with pre-existing comorbidities (uncontrolled diabetes mellitus, congestive heart failure, end-stage renal disease \[ESRD\], human immunodeficiency virus \[HIV\], and systemic lupus erythematosus \[SLE\]). * Patients with multiple organ dysfunction syndrome (MODS). * Patients with prior consumption of probiotics.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| White Blood Cells Level | From the day of randomization up to 5 days postoperatively | A white blood count measures the number of white blood cells (WBCs) in patients' blood. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Segmented Neutrophil level | From the day of randomization up to 5 days postoperatively | Segmented neutrophils are the most mature neutrophilic granulocytes present in circulating blood |
| Post operative pain level | From the day of randomization up to 5 days postoperatively | The Visual Analogue Scale (VAS) consists of a straight line with the endpoints defining extreme limits such as 'no pain at all' and 'pain as bad as it could be' |
| Length of Hospital Stay | From the day of randomization up to 5 days postoperatively | The duration of a single episode of hospitalization |
Countries
Indonesia
Contacts
STUDY_DIRECTORReno Rudiman, Professor
Hasan Sadikin General Hospital
Outcome results
None listed