Out of Hospital Cardiac Arrest
Conditions
Keywords
Out-of-hospital cardiac arrest patients, resuscitation,, artificial intelligence deep learning model
Brief summary
This study aims to establish an electronic medical record and imaging database for out-of-hospital cardiac arrest (OHCA) patients at NTUH Hsinchu Branch. Leveraging an AI deep learning model and an automated brain gray-white matter analysis system developed at NTUH, the research seeks to validate these tools externally. By integrating electronic medical records and brain imaging data, the project strives to enhance the accuracy of prognostic assessments, supporting physicians and families in decision-making for post-cardiac arrest care. Validation at Hsinchu Branch will assess the model's reliability across diverse medical settings and patient populations, optimizing its applicability and accuracy.
Detailed description
The purpose of this study is to establish an electronic medical record and imaging database for out-of-hospital cardiac arrest patients at National Taiwan University Hospital Hsinchu Branch. Our team have developed an AI deep learning model and an automated analysis system for brain gray-white matter based on data from National Taiwan University Hospital. These developments will be externally validated using the database at Hsinchu Branch in this project. Accurate prognosis assessment is crucial for physicians and families in making decisions regarding post-cardiac arrest care period. However, the current available assessment tools have limited accuracy. This study aims to develop a multimodal prognostic evaluation model that combines electronic medical records and the automated analysis system for brain graywhite matter. This integration will enhance the accuracy and predictive capability of prognosis assessment. The research team has already developed an automated analysis system for calculating brain gray-white matter ratio from brain computed tomography images, providing important information about pathological changes in the brain. Additionally, the team has also developed an AI-based predictive model for post-cardiac arrest prognosis, incorporating multiple indicators and variables. This system has been validated using data from National Taiwan University Hospital. To further validate the accuracy and reliability of our models, the research team plans to collaborate with Hsinchu Branch in collecting and organizing relevant data of post-cardiac arrest patients, including electronic medical records and imaging files. The developed automated analysis system for brain gray-white matter and the AI-based predictive model will be applied for external validation. Through this research, the goal is to establish and optimize a more comprehensive and accurate prognosis assessment model, assisting physicians and families in making better decisions for post-cardiac arrest patients. Furthermore, the collaboration with Hsinchu Branch will enable the validation of our models'applicability in different medical institutions and patient populations.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Patients at National Taiwan University Hospital Hsinchu Branch who experienced non-traumatic cardiac arrest between January 1, 2014, and December 31, 2020, and successfully achieved return of spontaneous circulation (ROSC) following resuscitation.
Exclusion criteria
1. Under 18 years of age; 2. Pregnant women; 3. Individuals who did not achieve successful resuscitation 4. Individuals without computed tomography (CT) imaging after resuscitation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral Performance Categories (CPC) Scale | From the time of ROSC achievement until hospital discharge or death, assessed up to 700 days | The Cerebral Performance Categories (CPC) scale is crucial for evaluating neurological outcomes in OHCA patients, providing a standardized framework to assess brain function and recovery after cardiac arrest. Ranging from CPC 1 (good recovery) to CPC 5 (brain death), it categorizes levels of neurological impairment, offering insights into the patient's prognosis. This scale is widely used in clinical and research settings to ensure consistent outcome measurement and facilitate comparison across studies. Additionally, it plays a vital role in guiding clinical decisions and discussions with families about post-resuscitation care and expectations, ultimately supporting better-informed decision-making. |
Countries
Taiwan
Outcome results
None listed