Alzheimer Disease
Conditions
Keywords
EEG, functional connectivity, neuroinflammation, nanoparticles
Brief summary
The variable course of Alzheimer's disease (AD) and the paucity of adequate cures urges to implement new strategies for its early detection and clinical intervention. Studying the etiopathogenesis and pathophysiological mechanisms of AD is a necessary prerequisite for the development of new biomarkers and innovative therapies. Contrarily to anatomical structures, cortical connectivity networks are already deteriorated in early AD and could be a reliable marker of early cognitive decline. Our aim is to characterize the neurophysiological parameters in mild AD, in patients with mild cognitive impairment and in matched healthy subjects to identify discriminating criteria. Concurrently, the study of AD onset and progression in a mouse model, will allow evaluating the causal effect of inflammation on disease progression and to develop a new class of biomimetic anti-inflammatory nanoparticles formulated to have the intrinsic ability to induce brain's activated microglia to an M2 phenotype.
Interventions
None listed
Sponsors
IRCCS San Raffaele Roma
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* mild AD and patients with mild cognitive impairment (MCI).
Exclusion criteria
* major psychosis, genetic, metabolic and other neurological disorders, acute or chronic non-compensated medical illness * any medical or drug-related condition affecting cognitive or mood status * history or current alcohol/illicit drug abuse.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of Disease-Associated Phenotypes in MCI and AD | through study completion, an average of 1 year | — |
| Identification of Disease-Associated Early Interventions in MCI and AD | through study completion, an average of 1 year | — |
| Predictive Power of EEG-Based Brain Network Analyses for MCI to AD Conversion | through study completion, an average of 1 year | EEG power spectral density |
| Evaluation of Targeting Efficiency of Activated vs Native Leukosomes in Brain Inflammation | through study completion, an average of 1 year | — |
| Evaluation Trafficking Kinetics of Activated vs Native Leukosomes in Brain Inflammation | through study completion, an average of 1 year | — |
| Assessment of Activated Leukosomes in Inducing Anti-Inflammatory Polarization of Macrophages | through study completion, an average of 1 year | — |
| Assessment of Activated Leukosomes in Glial Cells | through study completion, an average of 1 year | — |
Countries
Italy
Contacts
Primary ContactLucia Gatta, PhD
Outcome results
None listed