The Effect of Environmental Factors on Gastric Cancer Based on Macrogenome

Study on the Development and Prognosis of Gastric Cancer Based on Environmental Factors and Macrogenome

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06854146

Enrollment

200

Registered

2025-03-03

Start date

2024-11-01

Completion date

2027-11-01

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Air Pollution, Gastric Cancers

Keywords

Gastric Cancer, Macrogenome, Environmental Pollution, Air Pollution

Brief summary

The objectives of this study were to clarify how environmental factors such as air pollution affect the occurrence and development of gastric cancer; to identify patient-specific macrogenomic markers of gastric cancer; and to investigate the mechanism of gastric cancer development based on environmental factors and macrogenomic data.

Interventions

DIAGNOSTIC_TESTgastric cancer

patients diagnosed with gastric cancer

DIAGNOSTIC_TESThealthy

healthy participants

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* age ≥ 18 years; * patients with preoperative diagnosis of gastric cancer confirmed by pathologic biopsy; * no chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment; * willing to participate in the study and sign the informed consent form; * complete clinical data.

Exclusion criteria

* concurrent primary malignant tumor other than gastric cancer; * patients with systemic diseases, such as severe cardiopulmonary; * insufficiency, that affect the choice of treatment plan; * not suitable for enrollment as assessed by the investigator; * incomplete clinical data.

Design outcomes

Primary

Measure	Time frame	Description
Overall Survival (OS)	From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months	Description: Time from diagnosis to death from any cause, measured via medical records and follow-up interviews. Unit: Months

Secondary

Measure	Time frame	Description
Gut microbiome composition differences assessed by shotgun metagenomic sequencing	Tissue samples collected intraoperatively, sequencing completed within 1 week post-surgery.	Measuring Tool: Shotgun metagenomic sequencing (Illumina NovaSeq 6000). Analysis Parameters: Alpha diversity (Shannon index); Beta diversity (Bray-Curtis dissimilarity); Differential abundance of bacterial species (ANCOM-BC). Unit: Relative abundance (%) / Diversity indices.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026