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The Role of Root Canal Treatment in Alleviating Endodontic Pain-Induced Asymmetry and Restoring Muscle Balance

The Role of Root Canal Treatment in Alleviating Endodontic Pain-Induced Asymmetry and Restoring Muscle Balance: a Prospective Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06853028
Enrollment
20
Registered
2025-02-28
Start date
2023-09-01
Completion date
2024-08-01
Last updated
2025-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporomandibular Disorders (TMD), Acute Apical Periodontitis of Pulpal Origin

Keywords

root canal treatment, ultrasonography, endodontic pain, acute apical periodontitis, masticatory laterality

Brief summary

The study hypothesizes that masticatory laterality caused by acute apical periodontitis pain result in muscle asymmetry. Furthermore, it posits that successful root canal treatment, by restoring normal bilateral chewing function, will reduce this asymmetry, as evidenced by ultrasonographic measurements of the masseter and anterior temporal muscles.The main question it aims to answer is: Can bilateral chewing function be restored after root canal treatment procedures in patients with masticatory laterality due to painful teeth due to acute apical periodontitis?

Interventions

Muscle thickness measurements were performed with the ultrasound device immediately before root canal treatment, 1 week after, and 3 months after the treatment.

Sponsors

Cukurova University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

* Patients with masticatory laterality due to tooth pain for at least 30 days * First and second maxillary or mandibular molars with acute apical periodontitis due to deep caries * Teeth with moderate or severe pain according to the VAS (no pain (0 mm), mild pain (1-3 mm), moderate pain (4-6 mm), and severe pain (7-10 mm)) * Teeth that responded positively to percussion test * Teeth without periapical pathosis were included in the study.

Exclusion criteria

* Systemic conditions affecting muscle structure or function, such as neuromuscular or endocrine disorders. * Non-endodontic odontogenic pain. * Prior endodontic treatment of the relevant tooth within the last 30 days. * History of trauma or surgery to the head, face, or teeth within the last six months. * Severe communication disorders or psychological issues. * Inability to complete treatment in a single visit due to exudation or bleeding * Patients with masticatory laterality due to missing tooth on any side of the dental arch * Patients who have painful teeth in opposite sides of the dental arch * TMD patients were excluded from the study.

Design outcomes

Primary

MeasureTime frameDescription
Ultrasonographyimmediately before root canal treatment, 1 week after and 3 months after the treatmentUltrasound (also called sonography or ultrasonography) is a noninvasive imaging test. An ultrasound picture is called a sonogram. Ultrasound uses high-frequency sound waves to create real-time pictures or video of internal organs or other soft tissues, such as blood vessels. The masseter and anterior temporal muscle thicknesses of the patients were measured bilaterally using a high-frequency linear scanning probe (7 MHz) in B-mode of the Clarius Mobile Health ultrasound device (Vancouver, Canada). As no established formula exists to calculate muscle thickness asymmetry, the asymmetry index was based on another study in the literature. Asymmetry Index = \[(Control Side - Painful Side) / (Control Side + Painful Side)\] × 100

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026