the Effect of Environmental Factors on Colorectal Cancer Based on Macrogenomes

A Study of Colorectal Cancer Development and Prognosis Based on Environmental Factors and Macrogenomes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06852495

Enrollment

200

Registered

2025-02-28

Start date

2024-11-01

Completion date

2027-11-01

Last updated

2025-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer, Rectal Cancer

Keywords

Colorectal cancer, Macrogenome, Environmental pollution, air pollution

Brief summary

The aim of this study is to investigate the effects of environmental factors, such as air pollution, on the occurrence, development and prognosis of colorectal cancer; to identify metabolic markers specific to colorectal cancer patients, which will provide a basis for early diagnosis, early intervention and individualized treatment; and to comprehensively understand the mechanism of the occurrence and development of colorectal cancer by integrating the data of environmental factors and the macro-genome, and to develop new predictive and therapeutic strategies.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age ≥18 years old; * Patients diagnosed with colorectal cancer by pathologic biopsy before surgery; * Patients did not undergo chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment; * Willing to participate in the study and sign an informed consent form. Complete clinical data.

Exclusion criteria

* Concurrent primary malignant tumor other than colorectal cancer; * Patients with severe cardiopulmonary insufficiency or other systemic diseases that affect the choice of treatment plan; * Inappropriate for enrollment as assessed by the investigator; * Incomplete clinical data.

Design outcomes

Primary

Measure	Time frame	Description
prognosis	From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months	Overall survival (OS), from date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first.

Secondary

Measure	Time frame	Description
Macrogenomic differences	The date of macrogenomic testing, assessed up to 1 week after surgery.	Macrogenomic differences in feces.

Countries

China

Outcome results