Iron Deficiency Without Anemia
Conditions
Keywords
serum ferritin, oral iron supplementation
Brief summary
Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin following the administration of a daily iron dose for two months.
Interventions
DIETARY_SUPPLEMENTferrous sulfate 80 mg
1 tablet per day
DIETARY_SUPPLEMENTferrous sulfate 160 mg
2 tablets per day
Sponsors
Swiss Federal Institute of Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Low iron stores (SF levels \< 30 µg/L), * no anemia (Hb \> 120 g/L) * no inflammation (CRP \< 5 mg/L) * 18 to 45 years old. * Body weight \<70 kg * Normal body Mass Index (18.5-26.5 kg/m2)
Exclusion criteria
* Any chronic or acute disease * Consumption of mineral and vitamin supplements since screening and over the study period * Blood transfusion, blood donation or significant blood loss over the past 4 months, * Pregnant or breastfeeding, * Continuous/long-term use of medication during the whole studies (except for contraceptives) * Therapeutic iron infusion over the past 6 months, * Known hypersensitivity or allergy to iron supplements, * Intention to become pregnant over the course of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum ferritin | Study day 31 | Serum ferritin concentration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| alpha(1)-acid-glycoprotein | Study day 1 | alpha(1)-acid-glycoprotein concentration in serum |
| Serum ferritin | Study day 30 | Serum ferritin concentration |
| Serum Ferritin | Study Day 1 | Serum Ferritin concentration |
| Hemoglobin | Study day 1 | Hemoglobin concentration |
| C-reactive protein | Study day 1 | C-reactive protein concentration in serum |
Countries
Switzerland
Contacts
Primary ContactNicole Stoffel, PhD
Outcome results
None listed