NEC - Necrotizing Enterocolitis
Conditions
Brief summary
This prospective cohort study aims to investigate the impact of early antibiotic exposure on the establishment of gut microbiota and motility in newborns, particularly preterm infants. The study will explore the correlation between antibiotic exposure, gut microbiota colonization, and 5-hydroxytryptamine (5-HT) levels, which are critical for gastrointestinal motility. The findings may provide insights into optimizing antibiotic use and improving gastrointestinal health in neonates.
Interventions
None listed
Sponsors
The First Hospital of Jilin University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
24 Weeks to 36 Weeks
Healthy volunteers
No
Inclusion criteria
* Newborns admitted within 72 hours of birth * Gestational age 24-36 weeks (preterm) and term infants * Informed consent obtained from parents or guardian
Exclusion criteria
* Congenital gastrointestinal malformations (e.g., intestinal atresia, Hirschsprung's disease) * Severe systemic or organ-specific diseases * Expected mortality due to severe illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gut microbiota | Enrollment Period: This is the time during which participants will be recruited and enrolled into the study. You have specified that enrollment will occur from November 2024 to November 2027. Intervention Period: Since this is an observational study, the | Impact of antibiotic exposure on gut microbiota colonization assessed by 16S rRNA sequencing. |
Countries
China
Outcome results
None listed