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Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models

Jiangsu Provincial Hospital of Traditional Chinese Medicine

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06848959
Enrollment
2000
Registered
2025-02-27
Start date
2024-01-01
Completion date
2025-12-31
Last updated
2025-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorders, Cerebral Palsy, Mental Retardation, Tourette's Syndrome

Brief summary

Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood encephalopathy and a follow-up tracking question and answer system for childhood encephalopathy patients.

Interventions

OTHERNo intervention

Pediatric Encephalopathy Science and Prevention Decision Aid Follow-Up Q&A

Sponsors

Yun Liu,PhD
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
2 Years to 18 Years
Healthy volunteers
No

Inclusion criteria

* 1\. meet diagnostic criteria for CP ID TD ADHD ASD; 2. gender is not limited;

Exclusion criteria

* 1\. CP ID TD ASD due to chorea hepatomegaly hearing abnormality and pharmacogenetic factors; * 2\. Children with other major mental illnesses (e.g. schizophrenia) or organic diseases (e.g. congenital heart disease);

Design outcomes

Primary

MeasureTime frameDescription
Body temperature4 mouths
blood pressure (systolic, diastolic) after 10 minutes of rest4 mouths
Conners Rating Scales4 mouthsScores are converted to standardized T-scores for comparison with the mean of the peer group. T-scores above 65 are usually considered clinically significant.
tongue coating, pulse4 mouthsAfter obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of Pediatrics of Chinese Medicine.
respiratory rate4 mouths
Childhood Autism Rating Scale4 mouthsThe total score ranges from 15 to 60, with the higher the score the worse the symptoms are
meridian and acupointological features4 mouthsAfter obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of Pediatrics of Chinese Medicine.
Yale Global Tic Severity Scale4 mouthsIt has a score range of 0-100, with higher scores representing more severe symptoms.
Gross Motor Function Assessment Scale (GMFM)-884 mouthsGMFM-88 scores range from 0-264, with higher scores being better.
Autism Behavior Checklist4 mouthsIt has a score range of 0-174, with higher scores representing more severe symptoms.
acupuncture point status4 mouthsAfter obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of Pediatrics of Chinese Medicine.
Tongue texture4 mouthsAfter obtaining the information through diagnosis by a professional Chinese medicine practitioner, assist in the diagnosis of clinical subtypes of children according to the corresponding typology of Pediatrics of Chinese Medicine.
Wechsler intelligence scale (WIS)4 mouthsFIQ = 100: Indicates that the individual has an average level of intelligence. FIQ \> 100: Indicates an above average level of intelligence. FIQ \< 100: Indicates a below average level of intelligence.
Resting heart rate4 mouths

Secondary

MeasureTime frameDescription
blood4 mouthsDestruction after use. Metabolomics after sample collection.
Urine4 mouthsDestruction after use. Metabolomics after sample collection.
Faeces4 mouthsDestruction after use. Metabolomics after sample collection.
Saliva4 mouthsDestruction after use. Metabolomics after sample collection.

Countries

China

Contacts

Primary ContactYun Liu PhD
20200413@njucm.edu.cn+86 13023876996

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026