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Proton Pump Inhibitor Use and Dental Implant Success

Evaluation of the Relationship Between Proton Pump Inhibitor Use and Dental Implant Success: a Retrospective Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06848855
Enrollment
54
Registered
2025-02-27
Start date
2023-11-01
Completion date
2024-05-15
Last updated
2025-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Implant Survival and Success, Implant Survival Rate

Brief summary

The goal of this observational study is to evaluate the effects of proton pump inhibitors (PPIs) on the surrounding bone and the survival of dental implants. The main questions it aims to answer are: Does PPI use affect the survival rate of dental implants? Does PPI use influence crestal bone loss and fractal dimension (FD) of the surrounding bone?

Interventions

None listed

Sponsors

Berkay Tokuç
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Being over 18 years old, * Having a history of PPI use for more than six months, * Having at least one bone-level and axially placed dental implant in the maxilla or mandible, * Having a minimum of one year elapsed since the prosthetic restoration following dental implant placement, * Having undergone routine clinical follow-ups and radiological evaluations with periapical radiographs taken using the parallel cone technique after dental implant placement.

Exclusion criteria

* Individuals with a history of PPI use for less than six months, * Individuals with periapical radiographs of low image quality or with artifacts, * Individuals for whom the regions selected for fractal analysis on periapical radiographs are not appropriately sized, * Individuals who have not undergone routine clinical and radiographic follow-ups.

Design outcomes

Primary

MeasureTime frame
Fractal Dimension ValueFractal analysis values were calculated on radiographs within 1 month after the data collection of the patients.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026