Cerebral Desaturation Events, Spine Surgeries
Conditions
Brief summary
This study is to evaluate the effects of dexmedetomidine and magnesium sulfate on cerebral oxygen saturation in patients undergoing spine surgeries as adjuvant to general anesthesia guided by cerebral oximetry. The main aims to are Incidence of cerebral desaturation events and duration of cerebral desaturation events.
Interventions
PROCEDUREspine surgery
spine surgery in prone position
DRUGMagnesium sulfate
Patients will receive loading dose of 40 mg/kg of magnesium sulfate diluted in 50 ml of 0.9% saline IVI will be given in 10 min before anesthesia induction then continuous infusion of 10 mg/kg/hour during the surgery.
DRUGDexmedetomidine
Patients will receive loading dose of 1 mcg/kg dexmedetomidine diluted in 50 ml of saline 0.9% IVI will be given in 10 min before anesthesia induction then continuous infusion of 0.5 mcg/kg/hour during the surgery.
DRUGNormal Saline (0.9% NaCl)
Patients will receive the same volume of normal saline.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age from 21 to 60 years old. * either gender. * American Society of Anesthesiologists (ASA) physical status I and II.
Exclusion criteria
* Patient refusal to participate in research. * History of preoperative neuromuscular disease. * Patients with preexisting cerebral pathology (such as previous episodes of cerebral ischemia or stroke). * History of psychiatric illness. * History of orthostatic hypotension, myocardial infarction, uncontrolled hypertension or documented carotid stenosis. * Coagulopathy disorder. * Patients receiving magnesium supplementation. * Chronic use of opioids. * Current treatment with a β-blocker or calcium channel blocker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cerebral desaturation events. | intraoperative |
Secondary
| Measure | Time frame |
|---|---|
| Duration of cerebral desaturation events | intraoperative |
| change in heart rate in beats | intraoperative |
| change in blood pressure in mmHg | Intraoperative |
Contacts
Primary ContactIbrahim Elsayed Elnefiawy, assisstant lectuerer
Backup ContactNadia Elsayed Elafify, assistant lectuerer
Outcome results
None listed