Movement Disorders
Conditions
Brief summary
The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.
Interventions
OTHERPrescribed Medications
participant's movement disorders medications, prescribed by their treating physician
OTHERDeep brain stimulation adjustment
Deep brain stimulator parameters may be adjusted within normal clinical limits
Sponsors
University of Pennsylvania
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients 18 years of age and above * Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders: * Parkinson's disease * Dystonia * Tremor, including essential tremor * Cerebellar ataxia * Other hyperkinetic movement disorders, such as chorea and tics
Exclusion criteria
\- Patients with dementia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neural signal biomarkers | 5 years | Spatiotemporal patterns of brain neural activity (neural signal biomarkers / neurophysiologic signatures) associated with movement disorders symptoms. |
Countries
United States
Outcome results
None listed