Exercise, Metabolism
Conditions
Brief summary
Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance. The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.
Interventions
DIETARY_SUPPLEMENTKetone ester
0.29 g per kilogram body mass per hour of ketone monoester (R)-3-hydroxybutyrate (R)-3-hydroxybutyl
DIETARY_SUPPLEMENTPlacebo
Medium chain triglycerides and bitter tastant (Bitrex)
Sponsors
University of Bath
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* VO2max ≥ 45mL.kg-1.min-1 * Weekly aerobic training \> 3hours. * 2years running experience. * BMI \< 30kg/m2
Exclusion criteria
* \<18yrs or \>60yrs of age * Habitual smoker within last 5 years. * History of uncontrollable metabolic or respiratory disease. * Currently taking medication, following a low carbohydrate or ketogenic diet, or consuming nutritional ketone supplements. * History of Irritable Bowel Syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose concentrations | 240 minutes | Blood glucose concentrations during the recovery period (240 minutes) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Non-oxidative fate of ingested sucrose | 240 minutes | Non-oxidative fate of ingested glucose measured by appearance of 13C on breath CO2 from high 13C sucrose ingested during recovery |
| Exercise capacity | 240 minutes | Time to exhaustion running at 70% of maximal aerobic capacity after the recovery period |
Other
| Measure | Time frame | Description |
|---|---|---|
| Plasma insulin concentrations | 240 minutes | Plasma insulin concentrations during 240 minutes of recovery |
| Blood beta-hydroxybutyrate concentrations | 240 minutes | Blood beta-hydroxybutyrate concentrations throughout the 240 minute recovery |
| Blood bicarbonate | 240 minutes | Blood bicarbonate concentrations during 240 minutes of recovery |
| Blood pH | 240 minutes | Blood pH during 240 minutes of recovery |
| Urinary urea | 240 minutes | Urea in urine, determined by urea concentration multiplied by total urine output during the 240 minutes of recovery |
| Blood lactate concentrations | 240 minutes | Blood lactate concentrations during 240 minutes of recovery |
Countries
United Kingdom
Outcome results
None listed