Anesthesia, Traumatic Brain Injury
Conditions
Keywords
brain injury, intracranial pressure, mannitol, neurocritical care, osmolarity, trauma
Brief summary
This observational study is designed to research the effect of mannitol volume administration with changes in osmolarity in patients with traumatic brain injury to guide the safe use of mannitol in these patients.
Detailed description
This prospective observational cohort study included 64 non-operative TBI patients admitted to Dr. Kariadi Central General Hospital, Semarang, Indonesia, between November 2023 and January 2024. Patients received one of three routine clinical regimens: 3×0.25 g/kg, 2×0.5 g/kg, or 3×0.5 g/kg body weight. Mannitol was administered intravenously over 15-20 minutes per dose. Plasma osmolarity was measured at baseline and at 6 and 24 hours following initial administration.
Interventions
DRUGMannitol
mannitol administration across all three dosages given as an IV drip for 15-20 minutes
Sponsors
Universitas Diponegoro
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients aged 18-40 years * Glasgow Coma Scale (GCS) score indicating mild (14-13) or moderate (12-10)
Exclusion criteria
* Renal impairment * Multiple trauma with bleeding shock * Diabetes mellitus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Osmolarity | At baseline (before administration) and subsequently at 6 hours and 24 hours post-administration | Blood osmolarity (mOsm/L) |
Countries
Indonesia
Contacts
STUDY_DIRECTORAria P Hayanto, Sp.An-TI
Universitas Diponegoro
Outcome results
None listed