Healthy Volunteer
Conditions
Keywords
Kinesthetic motor imagery, Tendon vibration, Corticospinal excitability, Neuroplasticity, Electroencephalography
Brief summary
Kinesthetic motor imagery (kMI) involves imagining the sensations of movement, activating brain regions similar to actual movement execution. It is widely used to maintain or restore motor functions, particularly in rehabilitation. Tendon vibration (TV), which stimulates proprioceptive receptors can also enhance corticospinal excitability and promote neuroplasticity. This project investigates the coupling of kMI and TV through three modalities: simultaneous application, TV application between kMI trials, or pre-application of TV to precondition the nervous system before kMI trials. The effectiveness and quality of kMI will be assessed by corticospinal excitability measurements using transcranial magnetic stimulation and EEG measures. Conducting this study in healthy participants will inform the development of optimized clinical interventions for immobilized or mobility-reduced patients.
Interventions
DEVICETendon vibration (TV)
We use the VIBRAMOOV PHYSIO device which delivers local muscle vibrations at frequencies of 80 Hz and an amplitude of 1 mm.
OTHERKinesthetic motor imagery (kMI)
kMI is a mental technique in which an individual visualizes performing a movement without physically executing it. This process involves the internal representation of the sensations associated with the movement, engaging neural pathways similar to those activated during actual physical movement. kMI stimulates key motor and sensory areas in the brain, promoting neuroplasticity and enhancing motor performance.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Jean Monnet University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Men or women aged 18 to 50 years. * Affiliated with or beneficiaries of a social security system. * Provided written informed consent freely after being informed of the study's purpose, procedures, and potential risks.
Exclusion criteria
* History of pathology or surgery affecting upper limb motor function within 6 months prior to the study. * Chronic neurological, motor, or psychiatric disorders. * Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study period. * Contraindications to transcranial magnetic stimulation * Simultaneous participation in another interventional study or participation in such a study within 30 days prior to this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Optimization of kMI | 30 minutes | We will measure corticospinal excitability. This will be assessed by the area (in mV.%) under the curve representing the amplitude of motor-evoked potentials (MEPs, in mV) recorded via electromyography, as a function of transcranial magnetic stimulation intensity (in % of the stimulator's maximal output) required to evoke these potentials. |
Countries
France
Contacts
CONTACTLéonard FEASSON, PhD
CONTACTDiana RIMAUD, Doctor of Science
PRINCIPAL_INVESTIGATORLéonard FEASSON, PhD
Centre Hospitalier Universiatire de SAINT-ETIENNE
Outcome results
None listed